#038 Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation
FoundMyFitness
Rhonda Patrick, Ph.D.
4.8 • 5.5K Ratings
🗓️ 31 July 2017
⏱️ 70 minutes
🧾️ Download transcript
Summary
Dr. Guido Kroemer
Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy.
He is one of the most highly cited authors in the field of cell biology and was the most highly cited cell biologist for the period between 2007 and 2013. Especially notable among his contributions: he was the first to discover that the permeabilization of mitochondrial membranes is a concrete step towards apoptotic cell death.
In this episode, you’ll discover:
- 00:00:00 - Introduction
- 00:09:09 - The three main nutrient signals that activate autophagy
- 00:20:55 - The role of fasting and nutrient deprivation in autophagy
- 00:28:52 - Exercise induces autography
- 00:33:07 - Autophagy cleans out damaged organelles
- 00:35:14 - Mitophagy keeps mitochondria healthy
- 00:39:38 - Autophagy clears away neurodegenerative proteins in the brain
- 00:48:29 - Autophagy in cancer is a double-edged sword
- 00:54:52 - Fasting mimetics (e.g., resveratrol, spermidine, hydroxycitrate) induce autophagy
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/guido-kroemer
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Transcript
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| 0:00.0 | Welcome back, found my fitness podcast listeners. |
| 0:02.4 | Today's episode features Dr. Guido Chromer, |
| 0:04.9 | who was a professor at the University of Paris to Cart. |
| 0:07.8 | He is a cell biologist who has made major contributions |
| 0:10.6 | to understanding the role of mitochondria in cell death |
| 0:13.8 | and has published numerous studies in immunology, cancer |
| 0:17.1 | biology, aging, and autophagy. |
| 0:19.1 | The latter of which I'm especially interested in |
| 0:21.4 | because if you've listened to this podcast for a while, |
| 0:24.4 | you should be aware that autophagy is a very important process |
| 0:27.8 | for cleaning up cellular damage, which is intrinsic |
| 0:30.8 | to the aging process and cancer. |
| 0:33.2 | Autophagy may be an extremely important process |
| 0:36.0 | that interestingly can be triggered |
| 0:38.0 | through occasional periods of intense fasting. |
| 0:40.6 | It's not only related to fasting, |
| 0:42.7 | but that's an important connection. |
| 0:44.6 | This podcast is a little bit of a higher level one. |
| 0:47.3 | If you have trouble keeping up with it, |
| 0:48.8 | it is helpful to watch the video on YouTube |
| 0:51.1 | where definitions of scientific terms and figures are provided. |
| 0:54.6 | In fact, if you're wanting to learn more about autophagy, |
... |
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