Hello everyone, in today's podcast I interview Dr. Aubrey Degre.

Dr Degre is founder of the SENS Research Foundation, which aims to prevent and reverse aging by finding technologies that can repair the various types of damage that fuel the aging process.

In this episode we discuss what those types of damage are, how aging results in a decrease in the capacity to repair these types of damage, what role epigenetics plays in the aging process, how people age at different rates,

how chronic inflammation drives aging, some of the very interesting research that's been coming out showing that factors found in young blood can repair damage when infused into older organisms, the role of nutrition in aging, the advent of new highly precise gene therapy technologies like CRISPR and other exciting new emerging techniques like that of induced pluripotent stem cells.

Well I think Aubrey and I do come from slightly different schools of thought on some of the finer details I respect his role as an agent of change in how people view the inevitability of aging.

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And now on to the podcast with Dr. Aubrey DeGrey.

Dr. Ronda Patrick here and this adventure of the foundmyfitness podcast, I'm in Mountain View, California at the SENS Research Foundation and I have sitting here with me Dr. Aubrey Gray in the house.

Aubrey is a biomedical gerontologist and he is founder of the SENS Research Foundation and as far as I know the SENS Research Foundation has taken on quite a ambitious goal and that goal is to help prevent and cure aging.

And I think that Aubrey sometimes refers to aging as a disease and so I'd like to talk a little bit about that but thank you for being here Aubrey and can you please tell us a little bit about the SENS Research Foundation.

The SENS Research Foundation is a biomedical research charity so we're a 501c3 which means taxpayers can get tax benefits and they give us money.

And we do research into the diseases and disabilities of old age.

And I'm a little bit cautious in using words like killer and disease in relation to aging because we have to remember always that aging is a side effect of being alive.

It's like it's the consequence of the accumulation in the body of various molecular and cellular changes that are inevitable consequences of what the body does to keep us alive from one day to the next.

Those changes are things that I call damage and that damage is harmless for a long time because the body is set up to tolerate our certain amount of it but of course only a certain amount which means that eventually this damage exceeds our tolerance and we start to decline mathematically and physically and that's what the diseases and disabilities of old age are.

So when I talk about cures and about disease and what was a little bit careful I think that the oversimplification that most people make with regard to the difference between diseases on the one hand and aging on the other hand is extraordinarily damaging over simplification because it makes people unjustifiably over optimistic about the possibility of curing age related phenomena.

And that they do think of their diseases let's say Alzheimer's or cancer as a must-cancer or osteoporosis or whatever but it makes them also over pessimistic about medical advances to prevent and preempt the aspects of age related health that they don't think of as diseases like loss of muscle or decline function of the immune system or whatever.

The best way to think about this is that all of these things are part and parcel of the same phenomenon. They are interdependent but nevertheless individual aspects of the accumulation of molecular and cellular damage in the body and the only way that we're going to bring them under control is by developing a panel of interventions that we can use to periodically repair those various types of damage.

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