Welcome to Helix Talk, a podcast presented by the Rosalm Franklin University College of Pharmacy.

This podcast is produced by pharmacy faculty to supplement study material and provide relevant drug and professional topics.

We're hoping that our real-life clinical pearls and discussions will help you stay up to date

and improve your pharmacy knowledge.

This is an educational production copyright Rosalind Franklin University of Medicine and Science.

This podcast contains general information for educational purposes only. This is not professional advice and

should not be used in lieu of obtaining advice from a qualified healthcare provider.

And now, on to the show.

Welcome to Helix Talk, episode four. My name is Dr. Kane. And I'm Michael Schumann. And I'm Dr. Patel.

And today we're talking about P2Y-12 inhibitors and anti-platelet agents. The first agent we're talking about

today is Plavix. The generic name is Clopidigrel. And this is one of the older ones on the market.

Dr. Schumann, what is this compagulchial is used in?

This is one, as with some of the others, it can be used in a couple of different disease states, of course, all relating to cardiovascular health.

So acute coronary symptoms, myocardio infarctions, strokes, or peripheral artery disease are kind of the main areas in which it's used.

Sounds like it's approved for quite a few different things. At least in the ICU, the most

common indication I see it for is someone who's had a cardiac stint where they had a heart

attack, they got a stent placed, and now they're on this medication for a few months, depending

on the type of stent that was placed. And I guess we should kind of clarify how these agents actually work.

So they are anti-platelet agents, but I think we can do better than that in terms of how they work.

So they're anti-platelet in the sense that what they do is they block what's called ADPP2Y-12,

and it's a receptor on these platelets, so that by blocking that it then allows for, we have a decrease in aggregation,

and just to allow platelets instead of that clumping.

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