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PBS News Hour - Segments

Why Native Americans are facing high rates of mental decline

PBS News Hour - Segments

PBS NewsHour

News, Daily News

41K Ratings

🗓️ 8 December 2025

⏱️ 9 minutes

🧾️ Download transcript

Summary

It’s estimated that around 7 million Americans have Alzheimer’s disease, a number that’s expected to double by 2060. But researchers have found that some of the highest rates of cognitive impairment and dementia exist in a population that’s long been one of the most difficult to study: Native Americans. Stephanie Sy recently traveled to Seattle to understand why. PBS News is supported by - https://www.pbs.org/newshour/about/funders. Hosted on Acast. See acast.com/privacy

Transcript

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0:00.0

It's estimated that around 7 million Americans have Alzheimer's disease, a number that's

0:06.0

expected to double by 2060.

0:08.4

But researchers have found that some of the highest rates of cognitive impairment and dementia

0:13.1

exist in a population that's long been one of the most difficult to study, Native Americans.

0:19.3

Stephanie Syre recently traveled to Seattle to understand why.

0:22.6

And so this is a full-sized brain.

0:27.6

Inside this laboratory at UW Medicine in Seattle,

0:31.6

scientists study brains hands-on, both healthy and diseased.

0:36.6

And so in Alzheimer's disease, the brain atrophies it starts to shrink. brains hands-on, both healthy and diseased.

0:37.7

And so in Alzheimer's disease, the brain atrophies it starts to shrink.

0:42.5

Dr. Durk Keene leads the lab where more than 4,000 human brains are preserved for science.

0:49.4

So this person may have Alzheimer's disease, they may have Lewybody disease, they may have some tiny

0:56.0

little strokes that we call microinfarks, all contributing to their dementia.

1:00.0

Alzheimer's disease is marked by abnormal protein deposits in the brain.

1:05.0

This lab houses one of the nation's leading Alzheimer's projects.

1:09.0

You look at the microscope, it's so cool, right?

1:11.6

The goal, to analyze brain tissue in hopes of unlocking new treatments and cures for the

1:17.6

disease that is the leading cause of dementia among older adults.

1:22.6

The greatest gift you can give to science, I think, is your brain.

1:25.6

It's really the gift that keeps on giving. The brain bank depends on brain donations, some of which have been stored and studied for more than 40 years.

1:34.3

But there is a key gap. Among the thousands of brains in the repository, less than five have been donated from Native Americans.

1:43.3

So the fact that we don't have very many Native American donor brains

...

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