Where Immunology, Cell Biology, and Microbiology Meet—Dario Simões Zamboni—The Laboratory of Innate Immunity and Microbial Pathogenesis (Zamboni Lab)
Finding Genius Podcast
Richard Jacobs
4.4 • 1K Ratings
🗓️ 14 June 2020
⏱️ 39 minutes
🧾️ Download transcript
Summary
Dario Simões Zamboni is a professor in the Department of Cell Biology at the Ribeirão Preto Medical School, University of São Paulo, and he joins the show to discuss the ins and outs of his important and fascinating research.
In this episode, you'll discover:
- What type of cell death actually leads to an immune response capable of controlling the replication of pathogens in the body
- What types of parasites and bacteria are able to subvert the function of cells that are crucial to the immune response
- How innate immune memory works
Zamboni's research focuses on the interactions between host cells in the human body and microbial pathogens. According to Zamboni, understanding the processes that occur in relation to these interactions is key to understanding the outcome of certain diseases.
When a pathogen is able to replicate in the host's body, severe illness and even death can result, but under certain circumstances, the body can fight a pathogen and regain homeostasis. So, what dictates what will happen? This is one of the questions Zamboni spends his days investigating.
Of particular interest to Zamboni are the intracellular parasites Leishmania and Trypanosoma cruzi, and the intracellular bacteria Legionella and Coxiella burnetii. These pathogens are considered virulent, which means they are adapted to subvert the function of certain cells, such as macrophages which are integral to the immune response.
In the presence of these pathogens, macrophages are rendered unable to kill the pathogen or recruit other cells to kill the pathogen. Zamboni's goal is to better understand how exactly this process of modification by the pathogen works, and what exactly dictates whether the host or pathogen wins.
Among other topics, Zamboni talks in detail about the process of phagocytosis, pathogenesis, innate immune memory, the many receptors we have that are ready to sense the most abundant components of bacteria, and bacterial secretion systems for modulating immune cells.
Tune in and check out https://lpm.fmrp.usp.br/en/ to learn more.
Available on Apple Podcasts: apple.co/2Os0myK
Transcript
Click on a timestamp to play from that location
| 0:00.0 | Forget frequently asked questions. |
| 0:02.0 | Common sense, common knowledge, or Google. |
| 0:05.0 | How about advice from a real genius? |
| 0:07.0 | 95% of people in any profession are good enough to be qualified and licensed. |
| 0:11.0 | 5% go above and beyond. They become very good at what they do, but only 0.1% are real Jesus. |
| 0:18.0 | Richard Jacobs has made it his life's mission to find them for you. He hunts down and interviews geniuses in every field, sleep science, |
| 0:25.7 | cancer, stem cells, ketogenic diets, and more. Here come the geniuses. This is the Finding Genius |
| 0:32.1 | podcast that Richard Jacobs. This is the Finding Genius Podcast. |
| 0:33.0 | That is Richard Jacobs. |
| 0:35.0 | Hello, this is Richard Jacobs with the Finding Genius Podcast. |
| 0:41.0 | I have a Starrio Simo Samboni. |
| 0:44.4 | He's a professor of the Department of Cell Biology |
| 0:46.6 | at the Roberto Preto Medical School, |
| 0:48.9 | University of San Paulo. |
| 0:50.4 | So Dario, thanks for coming. |
| 0:51.9 | How you doing? I'm pretty good. |
| 0:53.0 | We should. |
| 0:54.0 | Thank you very much for inviting me. |
| 0:55.0 | It's a pleasure to be here. |
| 0:57.0 | So tell me about your work. |
| 0:59.0 | What's the, what are you working on overall? |
| 1:01.0 | So pretty much my lab focused on understanding the interaction. working on |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Richard Jacobs, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Richard Jacobs and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2026.