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The Human Upgrade: Biohacking for Longevity & Performance

What the Godfather of IF Eats - Mark Mattson, Ph.D. : 634

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

Fat, Health & Fitness, Meditation, Biohacking, Lifestyle, Diet, Science, Self-improvement, Fasting, Nutrition, Hacking, Fitness, Brain, Wellness, Education

4.67.3K Ratings

🗓️ 10 October 2019

⏱️ 86 minutes

🧾️ Download transcript

Summary

In this episode of Bulletproof Radio, my guest is one of the world’s top experts on the health benefits of intermittent fasting on the brain and body.

Decades before intermittent fasting diets became popular, Mark began studying mouse models to understand how the brain adapts to challenges like fasting and exercise. He and his research teams have shown that fasting can improve cognitive function and metabolic health. Early studies in humans now are underway.

“Intermittent fasting and exercise can reverse diabetes, and obesity in humans if a person can switch their eating pattern, and get on an exercise program,” Mark says.

His work on intermittent fasting has been featured on national media and he has given a TED Talk, “Why Fasting Bolsters Brain Power”. Our conversation in this episode covers a lot of ground, such as:

  • What happens during a fasted ketogenic state;
  • How to choose an intermittent fasting time period;
  • What and when Mark eats to obtain maximum intermittent fasting brain and body benefits;
  • How the mTor pathway is inhibited;
  • How autophagy acts as both a garbage disposal and a recycling bin; 
  • How the Nrf2-ARE antioxidant defense pathway is activated; and
  • How important nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are to brain health.


Mark currently is a professor of Neuroscience at Johns Hopkins University. He’s one of the foremost researchers in the area of cellular and molecular mechanisms underlying neurodegenerative disorders such as Alzheimer's and Parkinson's. Previously, he was chief of the Laboratory of Neurosciences at the National Institute on Aging Intramural Research Program (IRP) at the National Institutes of Health since 2000.

Enjoy the show!

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Transcript

Click on a timestamp to play from that location

0:00.0

So I think caffeine is good. I published an article in Scientific American in 2015 and the whole take home message of the article was that many of the chemicals that are in fruits, vegetables, tea, coffee, plants that are good for a health.

0:19.0

The actual reason they're in the plants, the evolutionary reason is that they're noxious agents, they're toxins. And caffeine is a good example. If you take pure caffeine and put it on your tongue, you wouldn't want to eat it. It's very bitter tasting.

0:35.0

Caffeines and natural pesticide produced by coffee beans and tea leaves. And if you take coffee beans or tea leaves and put them on your counter and put most any food next to it, and there's ants in your house, the ants will avoid the coffee beans and tea and they'll go for the other things that don't have the bitter tasting chemicals.

1:06.0

Bulletproof radio, a state of high performance.

1:10.0

You're listening to Bulletproof radio with Dave Asprey. I was grabbing a danger coffee with my friend the other day and out of the blue he said, Dave, what do you do for your skin?

1:19.0

I left it first because it's not like I have a complex skin care routine. But I do know that my skin is the largest organ in my body and it is the first line of defense against the world and it's really permeable if you don't take care of it.

1:33.0

So I do take care of my skin and one of the few things that I found that works noticeably is timelines skin health line. That's because timeline uses a fascinating new ingredient that invented called my topur that you've heard about on the show.

1:46.0

It's clinically improvement to support your cell's ability to make energy so you have healthier younger looking skin, which takes energy.

1:54.0

One of the things that makes timeline stand out to me is that there are lots of rigorous clinical trials showing that it works systemically and it works specifically on your skin.

2:03.0

It's made a big difference in how my skin looks and feels. So pay attention to your skin because it's an organ and you want all your organs to work right.

2:11.0

Check out timeline nutrition dot com slash Dave use code Dave skin that check out for 10% off when you're stacking your bio hacks.

2:19.0

One of the most important things you can do is make sure that you recover properly because you get rest that's when your body recovers.

2:27.0

In fact, that's part of the laziness principle from my book smarter not harder and one of the things I like to use is an infrared sauna like sunlight.

2:36.0

That's because you actually rest while you're in the sauna but more importantly it makes you get really good sleep at night.

2:43.0

There are tons of studies that show that sauna heat works really really well and the kind of deeply effective rest you get when you get out of the sauna is what recharges you physiologically and mentally.

2:56.0

Better yet because you're detoxing in the sauna you'll be able to handle the stress that you face every single day.

3:02.0

Sunlight has four sauna collections each has a different combination of light and heat and invest in your rest.

3:09.0

Go to sunlight and dot com slash Dave mentioned Dave asprey and you can save up to $600 on your son.

3:16.0

Today's cool fact of the day is that there are different ways to kick start intermittent fasting so it's easier for you.

3:24.0

If you don't know about intermittent fasting this is something I wrote about in the bulletproof diets and I've been doing for a very long time and basically you eat the same thing.

3:31.0

You're going to eat in a smaller eating window each day basically have just lunch and dinner skip breakfast or have just lunch and breakfast skip dinner.

3:41.0

It's pretty straightforward you want to eat about six or eight hours.

...

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