meta_pixel
Tapesearch Logo
Log in
Nutrition Diva

What are senolytics (and should you be taking them)?

Nutrition Diva

Macmillan Holdings, LLC

Nutrition, Food, Arts, Health & Fitness, Education

4.41.8K Ratings

🗓️ 16 April 2025

⏱️ 10 minutes

🧾️ Download transcript

Summary

These compounds are said to fight aging by clearing “zombie cells” out of your body. Is there any science to back this up?

References

Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial - PubMed

A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease - ScienceDirect

JCI - Strategies targeting cellular senescence

Targeting senescent cells: approaches, opportunities, challenges - PMC

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics - Zhang - 2023 - The FEBS Journal - Wiley Online Library

New to Nutrition Diva? Check out our special Spotify playlist for a collection of the best episodes curated by our team and Monica herself! 

We've also curated some great playlists on specific episode topics including Staying Strong as We Age, Diabetes, Weight Loss That Lasts and Gut Health! Also, find a playlist of our bone health series, Stronger Bones at Every Age

Have a nutrition question? Send an email to nutrition@quickanddirtytips.com.

Follow Nutrition Diva on Facebook and subscribe to the newsletter for more diet and nutrition tips. 

Find out about Monica's keynotes and other programs at WellnessWorksHere.com

Nutrition Diva is a part of the Quick and Dirty Tips podcast network.  


Hosted on Acast. See acast.com/privacy for more information.

Transcript

Click on a timestamp to play from that location

0:00.0

Have you heard about these compounds that promise to clear zombie cells from your body?

0:06.3

Well, today we're exploring the fascinating and still very new science of seniletics.

0:18.8

Hello and welcome to the Nutrition Diva podcast, a show where we take a closer look at the latest nutrition headlines, research, products, and trends, and sort fact from fiction.

0:31.9

I'm your host, Monica Reinagle, and today we're exploring some really fascinating new research on compounds that might actually help reverse aging at the cellular level.

0:44.3

Now, we've definitely heard this kind of thing before, right?

0:48.2

This type of claim, reversing aging at the cellular level, that is stock in trade for the multi-billion dollar supplement

0:56.3

industry, which sells an awful lot of supplements with very flimsy evidence to support them.

1:03.6

And indeed, the category of compounds that we're talking about today, Cenolytics, is already

1:09.4

being marketed as the latest anti-aging miracle.

1:13.3

Now, my goal today is not necessarily to give senoletics a thumbs up or a thumbs down

1:19.3

because I think it's far too soon to say. Instead, I want to brief you on what we do and don't yet

1:26.4

know about them so that if you do run across

1:29.4

these products or these claims, you've got a little background with which to assess them.

1:35.3

So let's start with this intriguing idea of zombie cells.

1:40.1

More scientifically known as senescent cells, these are cells that have been damaged or stressed

1:46.5

to the point where they stop dividing and they stop functioning, but they don't die off

1:53.1

the way healthy cells typically do. Instead, they hang around in the body, not doing anything

1:59.7

useful, and even worse, they secrete inflammatory

2:03.3

substances that can harm neighboring cells and tissues. Now, we all have some of these

2:10.0

senescent zombie cells floating around. As we age, they gradually accumulate in our bodies.

2:16.7

And one theory of aging is that it's this build-up

2:20.3

of senescent cells, which contributes to chronic inflammation, tissue damage, and is a major

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Macmillan Holdings, LLC, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Macmillan Holdings, LLC and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2026.