Week 3 of Thursday Night Football gives us the New York Giants vs the San Francisco 49ers. What are the biggest storylines of this game? With the Giants down their best offensive lineman Andrew Thomas and offensive player Saquon Barkley, where do they go from here? Being a balanced offense is important and protecting QB Daniel Jones is as important. Nick Bosa should be in the backfield often in this matchup with a back OT starting. Will RB Eric Gray help the Giants run the ball well enough in Barkley's absence? DP believes the Giants' defensive line will be pivotal to stopping Christian Mccaffery and forcing Brock Purdy to shoulder the offensive weight. Who wins this game will Keith and DP remain undefeated picking Thursday night games? Support Us By Supporting Our Sponsors! DoorDash Get fifty percent off your first DoorDash order up to a twenty-dollar value when you use code lockedonnfl at checkout. Limited time offer, terms apply. Jase Medical Save more than $360 by getting these lifesaving antibiotics with Jase Medical plus an additional $20 off by using code LOCKEDON at checkout on jasemedical.com. birddogs Go to birddogs.com/LOCKEDONNFL or enter promo code LOCKEDONNFL for a water bottle with any order. You won’t want to take your birddogs off we promise you. PrizePicks Go to PrizePicks.com/lockedonnfl and use code lockedonnfl for a first deposit match up to $100! Gametime Download the Gametime app, create an account, and use code LOCKEDONNFL for $20 off your first purchase. Last minute tickets. Lowest Price. Guaranteed. eBay Motors For parts that fit, head to eBay Motors and look for the green check. Stay in the game with eBay Guaranteed Fit. eBay Motors dot com. Let’s ride. eBay Guaranteed Fit only available to US customers. Eligible items only. Exclusions apply. LinkedIn LinkedIn Jobs helps you find the qualified candidates you want to talk to, faster. Post your job for free at LinkedIn.com/LOCKEDONNFL. Terms and conditions apply. FanDuel Make Every Moment More. Right now, NEW customers can bet FIVE DOLLARS and get TWO HUNDRED in BONUS BETS – GUARANTEED. Visit FanDuel.com/LOCKEDON to get started. FANDUEL DISCLAIMER: 21+ in select states. First online real money wager only. Bonus issued as nonwithdrawable free bets that expires in 14 days. Restrictions apply. See terms at sportsbook.fanduel.com. Gambling Problem? Call 1-800-GAMBLER or visit FanDuel.com/RG (CO, IA, MD, MI, NJ, PA, IL, VA, WV), 1-800-NEXT-STEP or text NEXTSTEP to 53342 (AZ), 1-888-789-7777 or visit ccpg.org/chat (CT), 1-800-9-WITH-IT (IN), 1-800-522-4700 (WY, KS) or visit ksgamblinghelp.com (KS), 1-877-770-STOP (LA), 1-877-8-HOPENY or text HOPENY (467369) (NY), TN REDLINE 1-800-889-9789 (TN) Learn more about your ad choices. Visit podcastchoices.com/adchoices