We Can Now Drive Aging Forward and Backward at Will — Here's What That Means | Impact Theory W. Tom Bilyeu Dr. David Sinclair
Tom Bilyeu's Impact Theory
Impact Theory
4.7 • 5.2K Ratings
🗓️ 18 April 2026
⏱️ 82 minutes
🧾️ Download transcript
Summary
Welcome back to Impact Theory with Tom Bilyeu. In this electrifying continuation, Tom Bilyeu dives deep with world-renowned aging researcher Dr Sinclair to explore the cutting edge of anti-aging science and regenerative medicine. Prepare for a mind-bending journey through lab-grown “mini brains,” the ethics of creating organs from scratch, and the real-world implications of reversing aging—in everything from skin and hair to the human brain and spinal cord.
You’ll hear insights on the latest advances in using AI to develop longevity drugs, the surprising possibilities for reversing age-related infertility, and how upcoming clinical trials may soon change the way we think about disease, aging, and human potential. Plus, Dr Sinclair shares his personal health protocol and practical strategies for extending your lifespan today, all while tackling big questions about the future—from living to 1000 years, to the cautionary tales and optimism inherent in this rapidly evolving field.
Get ready for a conversation that bridges science fiction and reality as Tom Bilyeu and Dr Sinclair unpack what it means to truly disrupt aging.
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micro brains, stem cells, brain organoids, blood vessel cells, pituitary gland, calcium imaging, ethical questions in science, aging models, AI in biology, gene therapy, chemical cocktails, clinical trials, phase one trials, sirtuin activators, NAD IV, fertility reversal, uterus regeneration, brain health supplements, ketones, intermittent fasting, DNA methylation, gene expression, Alzheimer's disease, amyloid plaques, optic nerve regeneration, glaucoma treatment, skincare de-aging, hair regrowth, statins, metformin, anti-cancer nutrition
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Transcript
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| 0:00.0 | Welcome back to part two of this incredible conversation. Without further ado, here we go. |
| 0:09.2 | Okay, so you guys are able to replicate micro brains. How do you make them small? Well, we grow |
| 0:16.1 | them from single cells. We turn them into stem cells. Would they just keep growing and growing and |
| 0:20.3 | growing and growing if you fed them? They reach a certain size where they don't keep growing because they don't |
| 0:26.0 | have blood vessels. Do they have a pituitary gland? They don't have blood vessels. I don't know if |
| 0:30.5 | they're pituitary. How do they stay alive? We shake them in liquid and the oxygen diffuses through, |
| 0:36.9 | but if they get too big, the core becomes hypoxic |
| 0:39.8 | and doesn't grow well. But what we need to do is to mix them with blood vessel cells, which |
| 0:44.5 | people are working on, and then we could grow them really big. This is so interesting. Oh my God. |
| 0:51.6 | And then it's ethical questions about if you can grow a brain from scratch, should you teach it something? Should you give it something to think about? |
| 1:00.1 | Yes. Anyway, it's a good model for aging. Dude. So wait, there are, it's my understanding, AI that right now can do like these really rough like this person is thinking about this. And it like shows you like a horse. And you're like, it's kind of a horse. It's just like sort of blobby shapes. We need to apply immediately this AI to these brains. I need to know if these things are like screaming out. I'm bored, bro. Like come on. Give me something to do. This is wild. |
| 1:28.0 | Okay. |
| 1:28.3 | I love everything about this. |
| 1:29.4 | And here's the other thing is we see them get old. |
| 1:32.5 | They lose their firing. |
| 1:33.9 | And we can look at them in real time. |
| 1:35.5 | They're actually, you see these sparks, like looking at fireworks. |
| 1:39.3 | When they get older, there's fewer sparks. |
| 1:41.9 | How are you monitoring the brains? |
| 1:46.0 | Well, you put them on the microscope and we can see calcium changes. When calcium gets sent into the nerve cells when they get |
| 1:55.2 | calcium, they light up. Under the microscope, though, are they now dying at this point? No, |
| 2:00.1 | they're living. We can put them back. |
... |
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