Vitamin B12 Pharmacology
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist
4.9 • 773 Ratings
🗓️ 29 April 2021
⏱️ 14 minutes
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Summary
On this episode, I cover clinical tips and practice pearls surrounding vitamin B12 pharmacology.
Vitamin B12 deficiency plays a critical role in the development of macrocytic anemia.
There are medications that you have to be aware that can deplete vitamin B12. Metformin, colchicine, and PPIs are some common examples.
A lack of intrinsic factor can lead to B12 deficiency. Intrinsic factor is necessary for adequate GI absorption of vitamin B12.
I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.
Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!
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Transcript
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| 0:00.0 | Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen. |
| 0:06.2 | Thanks so much for listening. As always, be sure you check out Real Life Pharmacology.com. |
| 0:11.4 | Snaggy your free 31-page PDF on the top 200 drugs. Great little study guide reference for those folks maybe going through pharmacology classes or if you've |
| 0:22.4 | been out in practice for a while and just want a little refresher make sure you're staying up to |
| 0:26.2 | date definitely a cool little resource to check out and it's free absolutely free for subscribing |
| 0:32.1 | all right so let's talk about the drug of the day today medication is cyanocobalamin which is |
| 0:40.9 | vitamin b12 now some may not consider this a medication per se since it is a supplement and a |
| 0:49.3 | nutritional intake type of thing but i do and know, the reason being is that we certainly can dose it. |
| 0:59.6 | And obviously, it can be used to treat deficiency. And there are a bunch of medications, or a few |
| 1:07.6 | medications that I definitely look out for when I see in order for B12. |
| 1:14.0 | And I'll talk about that as I wrap up the podcast later in drug interactions for sure. |
| 1:19.8 | So what is vitamin B12 used for? |
| 1:23.2 | What's it good for in the body? |
| 1:25.6 | The most common indication I would say I see in practice is pernicious |
| 1:31.6 | anemia. Now what is, you know, pernicious anemia compared to, you know, generalized |
| 1:37.2 | anemia? Well, pernicious anemia specifically involves lack or low amounts of intrinsic factor. |
| 1:48.5 | Now, what's intrinsic factor? |
| 1:50.0 | Well, intrinsic factor aids in the absorption or is necessary for gut absorption of B12. |
| 1:58.0 | So in patients that don't have this intrinsic factor, odds are likely they're not getting enough B12. So in patients that don't have this intrinsic factor, odds are likely they're not getting |
| 2:04.1 | enough B12 in their diet through their food because they can't absorb it that well through the gut |
| 2:10.6 | because they don't have this intrinsic factor or an inadequate amount of intrinsic factor. |
| 2:17.3 | So long story short, these are the patients that you're or an inadequate amount of intrinsic factor. |
... |
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