Using 3D Patient-Derived Organoids to Better Understand Pancreatic Cancer—Herve Tiriac

Finding Genius Podcast

Richard Jacobs

Medicine, Health & Fitness

4.4 • 1K Ratings

🗓️ 28 January 2020

⏱️ 35 minutes

🔗️ Recording | iTunes | RSS

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Summary

Organoid modeling can be done using adult human tissues, mouse models, or by engineering induced pluripotent stem cells (iPS). At UC San Diego Health, Associate Project Scientist, Herve Tiriac, is using adult tissues to create 3D patient-derived pancreas-like organoids.

He discusses the following:

What portion of the pancreas is modeled in pancreatic ductal adenocarcinoma tumor organoids
What happens when different cell types are cultured together
How models can be created using only the tissue from fine needle biopsies
What types of variation are present in pancreatic tumors

Driven by both professional and personal reasons, Dr. Tiriac is interested in using 3D patient-derived organoid modeling in order to better understand pancreatic ductal adenocarcinoma, a type of cancer that's both very deadly and understudied. He sees this research as an opportunity to implement meaningful clinical improvement in the lives of those affected, and build a precision medicine technology platform in doing so.

Dr. Tiriac discusses the origination of the term "organoid" and the types of organoid modeling that can be done, the process of the development of organoids based on patient-derived pancreatic tumors, the challenge of organoid contamination by yeast and/or fungi, what types of new experimentation will be done in the near future, such as those dealing with the problem of treatment resistance and improving existing approaches to the development of tumor organoids, and so much more.

Tune in to hear the full conversation

Transcript

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0:58.0	Thank you. Hello, this is Richard Jacobs with the Future Tech and Finding Genius Podcast series.
1:09.4	I have Erve Turek, he's an associate project scientist at UC San Diego Health.
1:15.0	And we're going to talk about developing precision medicine platforms, and specifically 3D organoid modeling, patient-derived organoids, which I've spoken about a few times.
1:25.8	So, everybody, thanks for coming.
1:28.2	Thank you so much for having me.
1:29.2	I really appreciate it.
1:30.2	Yeah, I don't know if, I think I've asked this before so patient derived organoids can you just describe that process and if it's not patient derived where do these cells come from to make an organoid?
1:41.0	Yeah, so the term organoid is actually it's actually quite an old term but recently has been associated with the
	...

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