TWiV 984: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 18 February 2023

⏱️ 43 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode The political polarization of COVID-19 treatments in the United States (PNAS) Seven alternatives to evidence-based medicine (BMJ) Malawi’s cholera death toll crosses 1,300 (CBC) Impact of coronavirus infections on pediatric patients (JHI) Maternal mRNA COVID-19 vaccination during pregnancy (BMJ) Yes, masks reduce the risk of spreading COVID (TVO) COVID-19 and airborne transmission (IDSA) What were the reasons for resistance to recognizing airborne transmission (IJIE) Comparing Omicron-containing boosters with COVID-19 vaccine mRNA-1273 (medRxiv) SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster (bioRxiv) The impact of SARS-CoV-2 vaccine dose separation and targeting (Nature) Intra-host evolution provides for the emergence of SARS-CoV-2 variants (ASM) Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 (The Lancet) Viral rebound in hospitalized patients with COVID-19 receiving oral antivirals (The Lancet) Guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19 (CID) Contribute to our ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 984 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From micro TV, this is twiv this week in virology episode 984 recorded on February 16th,
0:20.8	2020-23. I'm Vincent Racken, yellow and you're listening to the podcast all about viruses.
0:27.0	Joining me today from New York, Daniel Griffin. Hello everyone. I haven't seen you in a long time,
0:34.5	Daniel. It's been a while. It's been minutes. And then I spent two hours recording something else just
0:41.4	now. We're tired of hearing each other, but hopefully you're not. Yeah. All right. Well,
0:47.2	let's get right into it. We have a lot to cover today. Yes, there will be one point in time when
0:51.6	hopefully I did not say that, but we will start off with our quotation when people talk, listen
0:57.8	completely. Don't be thinking what you're going to say. Most people never listen. And that's from
1:02.7	Ernest Hemingway across the river and into the trees written in 1967, the year I was born.
1:08.8	I will admit to being a huge Ernest Hemingway fan, but let us start off with the brief report,
1:15.1	the political polarization of COVID-19 treatments among physicians and laypeople in the United
1:21.5	States published in PNAS. So the most disturbing part of this study is that it underscores that
1:28.8	many physicians, so-called experts, are forming their opinions based not on reading the actual
1:35.3	scientific publications, but rather instead from the media. So in this study, the participants read
1:42.0	an abridged research abstract, that's for the physicians, or a research summary written in a
1:48.4	journalistic style, as for the laypeople, both of which reported the results of the together trial,
1:55.1	a well-powered randomized control trial that failed to find evidence that an anonymous therapeutic
2:02.3	GL-22 was effective for treating COVID-19. First, they listed beliefs about the studies in
2:09.2	formativeness, its methodological rigor and the likelihood that its authors were biased. Then,
2:16.7	they identified the GL-22 as Ivermectin. Participants who were more conservative now reported
2:24.0	that the evidence was less informative. The study was less methodologically rigorous,
	...

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