TWiV 982: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 11 February 2023

⏱️ 49 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities, incidence of chronic spontaneous urticaria following receipt of the COVID-19 vaccine booster in Switzerland, relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients, early treatment with pegylated interferon lambda for COVID-19, and how long-term high-dose immunoglobulin successfully treats long COVID patients with pulmonary, neurologic, and cardiologic symptoms. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Consistency of COVID-19 trial preprints with published reports (BMI) Negative effect of preexisting immunity on Influenza vaccine (JID) Highly pathogenic avian influenza infection in farmed minks (Eurosurveillance) Peru confirms H5N1 avian flu in marine mammals (CIDRAP) Prior vaccination enhances immune responses during SARS-CoV-2 infection (bioRxiv) Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and respiratory infections (CMI) Incidence of spontaneous Urticaria following COVID-19 vaccine booster (JAMA) Relationship between immune response to SARS-CoV2 vaccines and breakthrough infection in transplant recipients (CID) Early treatment with Pegylated Interferon Lambda for COVID-19 (NEJM) Long-term high-dose immunoglobulin successfully treats Long COVID patients (Frontiers) Contribute to our ASTMH fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 982 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.6	From microbe TV, this is Twiv, this week in virology, Episode 982, recorded on February 9th, 2023.
0:22.2	I'm Vincent Drakenello, and you're listening to the podcast all about viruses,
0:27.0	joining me today from New York, Daniel Griffin. Hello everyone. So tell me, Daniel, what's more
0:35.2	frequent at the moment, influenza, RS, or COVID? You know, none of the above.
0:41.5	Okay. It is important, I always say to like not just, you know, what am I seeing in my own backyard,
0:48.1	but what's going on around the country? Because, you know, here in New York,
0:51.5	you know, we are really doing great when it comes to all of these. Actually, as a country, you know,
0:57.9	the flu, it peaked, it came down, RSV, peaked, came down, COVID locally, peaked, and came down.
1:05.8	But, you know, it's sort of moving across the country. So we kind of got the COVID peak a little bit
1:13.2	earlier. So still, still hearing problems across the country. But, boy, flu and RSV are really down
1:19.2	everywhere. That's good. Yeah, it is, it is. Let's get right into it with the quotation.
1:27.2	The greatest friend of truth is time. Her greatest enemy is prejudice, and her constant companion is
1:34.8	humility. And this is by Charles Caleb Colton. I don't know, Charles Caleb Colton very well, but I
1:42.9	just love this quotation about how, you know, it takes time to get the truth. And the more time goes
1:49.6	by the more things become clarified there. So right up front, I want to share the article,
1:56.8	consistency of COVID-19 trial preprints with published reports and impact for decision-making,
2:03.2	retrospective review published in BMJ medicine. Our listeners are aware that during the pandemic,
2:09.2	we often would discuss preprints and even discuss how reviewing preprints should perhaps be part
2:15.3	of graduate and medical education. We'll hear in this paper after reviewing 365 trials, 101
2:23.5	available as preprints. The authors reported that they found no compelling evidence to indicate
2:28.4	that preprints provided results that are inconsistent in general with published papers. They sort
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