TWiV 978: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 28 January 2023

⏱️ 39 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Codetections of other respiratory viruses among children with COVID-19 (Pediatrics) Preprint review should form part of PhD programmes and postdoc training (Nature) Early and increased Influenza activity among children (CDC) COVID-19 vaccines versus pediatric hospitalization (Cell) SARS-CoV-2 variant abnormalities detected by prenatal MRI (The Lancet) Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity (The Lancet) Persistent COVID-19 symptoms at 6 months and role of vaccination (JAMA) Effects of Dexamethasone use among patients with COVID-19 (IJID) Impact of vaccination on sequelae of SARS CoV-2 in patients with rheumatic diseases (BMJ) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 978 Don’t crush Paxlovid (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From microbe TV, this is Twiv, this week in virology. Episode 978 recorded on January 26,
0:20.4	2023. I'm Vincent Racken Yellow and you're listening to the podcast all about viruses.
0:26.4	Joining me today from New York, Daniel Griffin. Hello everyone.
0:33.6	Daniel, I spent the day on the campus of NIH and I would like to report that research is
0:39.2	all well and good there. Okay, well I am glad to hear that. Well that's perfect for our quotation,
0:48.5	because our quotation is actually about science, which is something that I think our listeners
0:54.3	either share a love for or just are lost and you know listening to the wrong podcast, but I will say
1:01.6	the quotation. The good thing about science is that it's true whether or not you believe in it
1:07.7	and that's Neil de Grasse Tyson. I love it. That is one of my favorite quotations.
1:17.2	So I'm going to put this first article right up front as I'm hoping we have effectively
1:22.4	dispelled the idea that a patient can have only one thing going on at a time and as I like to say,
1:28.4	Acom was not a physician, a patient can have as many diseases as they please. I've cleaned that
1:33.9	up a little. The article, Code Detections of Other Restory Viruses Among Children Hospitalized
1:39.8	with COVID-19 was published in the journal Pediatrics. Remember the days when certain large
1:45.6	healthcare systems would not let you do a COVID test if the patient had a positive flu test.
1:49.9	In this study, the investigators looked at over 4000 children hospitalized between March 2020 to
1:57.6	February 2022 with SARS-CoV-2 infection admitted primarily for fever, respiratory illness or presumed
2:05.6	COVID-19. They compared demographics, clinical features and outcomes between those with and without
2:12.0	code detections who had any non-SARS-CoV-2 virus testing among a subgroup of 1,670 children
2:20.3	with complete additional viral testing. They described the association between the presence of
2:26.0	code detections and severe respiratory illness using age-stratified multi-variable logistic regression
	...

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