TWiV 972: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 7 January 2023

⏱️ 42 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature) Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv) Antibody evasion properties of BQ and XBB subvariants (Cell) Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature) Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI) Paxlovid patient eligbiliity screening checklist (FDA) COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature) Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell) SARS-CoV-2 infection and persistence in the human body and brain at autopsy (Nature) Long-term cardiovascular outcomes of COVID-19 (Nature) Heart-disease risk soars after COVID (Nature) Contribute to our MicrobeTV fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 972 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From micro TV, this is TWIV, this week in virology, episode 972 recorded on January 5th, 2023.
0:21.8	I'm Vincent Racken yellow and you're listening to the podcast all about viruses, joining me today from New York.
0:28.8	Daniel Griffin. Hello everyone. Well, here we are, first episode of 2023. Is it all downhill from here? Uphill.
0:40.6	Fortunately, Alex, looks like we're heading uphill again.
0:45.3	So yeah, we will be getting into that, but let me get right into it.
0:51.0	At one point, I will fulfill my promise of making these briefer, but we're not quite there yet.
0:56.6	So I'll start off with my quotation. I like the dreams of the future better than the history of the past.
1:04.0	And who is that by Thomas Jefferson? I was a bit surprised when I ran across that quotation.
1:09.8	But I know a lot of people are still sort of rehashing, what did we do wrong, what went wrong?
1:16.8	Well, maybe it would be important to think about how to do this right when we reflect on what's
1:22.5	happening over in China at the moment. So let's start off with the influenza, what's happening with
1:31.9	influenza? And actually for Vincent's viewing pleasure, I put up actually this graphic where you
1:40.7	can see the percentage of outpatient visits for respiratory illness reported by the US outpatient
1:46.7	influenza-like illness surveillance network, the Ili net, and they do this weekly national summary.
1:52.9	And the nice thing is they overlay prior seasons, because I don't want people to get lulled into a
1:59.6	sense of, you know, it's all over with flu, because characteristically, we'll have this rapid rise,
2:07.2	things will start to go down, and well, other than 2021, 2022 last year, which is a little bit odd,
2:13.3	we then see a rise again. So you just have to keep an eye on this. And why do we see this? What do
2:20.9	we think explains this pattern? Part of it we think is travel, right? So it goes up, and then it
2:27.6	starts to go down, and then, you know, so we will see what happens with influenza. It's still
2:32.4	actually higher than it was in a few years here. But yeah.
	...

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