TWiV 918: COVID-19 clinical update #123 with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 16 July 2022

⏱️ 41 minutes

🔗️ Recording | iTunes | RSS

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Summary

In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Monkeypox outbreak rapid testing response (CDC) Leading causes of death during pandemic (JAMA) FDA recommends vaccine update (FDA) Antibody evasion by subvariants (Nature) Broadly-Neutralizing antibodies against variants (Frontiers in Immunology) Severe outcomes factors in immunocompromised adults (CDC) Measurement of the burden of hospitalizations (OFID) Vaccine hesitancy among parents (Academic Pediatrics) PAXLOVID patient eligibility screening checklist (FDA) Remdesivir fact sheet for providers (Veklury) Bebtelovimab fact sheet for providers (FDA) Saliva evaluation to improve diagnostics (ASTMH) Oral Sabizabulin for high-risk adults (NEJM) Lower risk of MIS-C in children (CID) Neurovascular injury during infection (Brain) Paul Offit on TWiV 917 Contribute to FIMRC fundraiser at PWB Dr. Griffin’s treatment guide (pdf) Letters read on TWiV 918 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.3	From micro TV, this is Twiv, this week in virology, Episode 918 recorded on July 14th, 2022.
0:20.9	I'm Vincent Drakin Yellow and you're listening to the podcast all about viruses. Joining me today from
0:27.4	New York, Daniel Griffin. Hello everyone. Daniel, I can't believe it. The headlines are screaming,
0:36.0	scientists are concerned about BA5, the word SARS-CoV-2 ever. Here we are at clinical update 123.
0:46.9	It is not over. So let's get into it because as always, we have a lot to cover. So I'll start with
0:53.0	my quotation and I'm sure I will mispronounce this gentleman's last name, but the folly of mistaking
1:02.1	a paradox for a discovery, a metaphor for a proof, a torrent of verbiage for a spring of capital
1:10.0	truths and oneself for an oracle is inborn in us, Paul Valhlery. I just thought that that was a
1:17.6	nice reminder as we're two plus years into the pandemic about the eloquence-based medicine that
1:25.3	I mentioned early on. Just because someone makes a nice cartoon and shares it along with a few
1:33.0	anecdotes on social media or another platform, it does not magically become true. Science is not
1:38.7	about what feels true. It is about what the data shows to be true. No data, no science. I figured
1:45.2	you would be on board with those comments, Vincent. I like it. I like it very much. I also think that
1:50.4	another way of putting that is just because there are a lot of subjects in a study. It doesn't
1:55.6	mean that it's universal. That's true. All right. Well, on our clinical update, I just want to get
2:04.3	monkeypox out of the way. Remind people of the history. This actually started as a way to keep
2:10.3	clinicians up to date in the early days of COVID. I have to say I'm now getting a similar number
2:16.9	of frantic calls and texts about the monkeypox. Just a brief start here before we get back to COVID.
2:24.8	The MMWR early release rapid diagnostic testing for response to the monkeypox outbreak,
2:32.0	laboratory response network, United States May 17 through June 30, 2022. As a part of
2:39.9	public health preparedness for infectious disease threats, the CDC collaborates with other U.S.
	...

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