TWiV 1307: My heart breaks for flu

This Week in Virology

Vincent Racaniello

Virology, Science & Medicine, Pathogen, Infection, Virus, Racaniello, Twiv, Vincent, Microbe, Medicine, Infectious, Microbiology

4.8 • 2.2K Ratings

🗓️ 22 March 2026

⏱️ 113 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV reviews the structural basis for Rep-mediated adeno-associated virus DNA genome packaging, how influenza virus-infected myeloid cells travel to the heart and infect cardiomyocytes, leading to IFN-fueled heart damage. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) Robin Weiss passes (ICR) Judge strikes down RFK Jr.’s vaccine policies (NYTimes) How Rep protein packages AAV DNA (Cell Rep) How influenza virus causes heart damage (Immunity) Influenza virus hitches a cellular ride to the heart (Cell Host Microbe) Letters read on TWiV 1307 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – The math of March Madness brackets Kathy – SpaceX launch plume, jellyfish APOD and Cleveland Meteor, map of meteorites fall and a doorbell cam photo Rich – After barista’s tips were stolen, strangers showed up with $900 Vincent – What Causes Gravitational Time Dilation? A Physical Explanation. Listener Pick Charles – They’re Made Out Of Meat Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This week in Virology, the podcast about viruses, the kind that make you sick.
0:10.3	From MicrobTV, this is Twiv. This week in Virology, episode 1307 recorded on March 20, 26.
0:21.6	I'm Vincent Rackeniello, and you're listening to the podcast All About Viruses.
0:28.6	Joining me today from Madison, New Jersey, Brianne Barker.
0:33.6	Hi, great to be here.
0:35.6	It's not a bad day in Madison.
0:38.2	It's 63 Fahrenheit, which is pretty nice, although it is a bit overcast.
0:42.9	But I'm happy to see a little bit of warmth.
0:48.5	It's 15C here.
0:50.3	That's like tropical compared to what it's been.
0:52.9	Exactly.
0:54.7	Also joining us from Ann Arbor, Michigan, Kathy Spindler.
0:58.7	Hi, everybody.
0:59.5	If it's 16 there, that means it's 61 Fahrenheit.
1:03.0	There you go.
1:03.8	Yeah.
1:03.9	So here it's 68 Fahrenheit and it's 20 degrees Celsius and blue sky and not any clouds.
1:12.4	It's just really nice, 68 degrees.
1:15.0	Wow.
1:15.9	What just happened in Michigan of note?
1:17.9	Something happened.
1:19.4	Hmm.
	...

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