TWiV 1275: An amazing sequence and a gutsy therapy

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 30 November 2025

⏱️ 109 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine. Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Immune 100 live at the Incubator Spliced segments of adenovirus mRNA (PNAS) An amazing sequence in adenovirus mRNA (Cell) Nobel Prize for mRNA splicing (Nobel) A predominant undecanucleotide in adenovirus late mRNAs (Cell) Splicing RNA with Phillip A. Sharp (ASM) Protein production in the gut by engineered phage (Nat Biotech) Engineered phage T4 (Curr Op Virol) Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – Can You Identify These Lines from Classic SciFi Novels? Kathy – Saturday Morning Physics, Photograph 51 and JCE article Rich – Wikipedia:Wiki Science Competition 2025 in the United States Jolene – Data visualization workshop Vincent – Transformer: The Deep Chemistry of Life and Death by Nick Lane Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This Week in Virology, the podcast about viruses, the kind that make you sick.
0:10.4	From MicrowTV, this is Twiv.
0:13.4	This week in Virology episode 1275 recorded on November 28, 2025.
0:22.3	I'm Vincent Rackenielo, and you're listening to the podcast, All About Viruses.
0:28.5	Joining me today from Ann Arbor, Michigan, Kathy Spindler.
0:32.2	Hi, everybody.
0:33.3	Here, it's 31 degrees Fahrenheit, but it says it feels like 14. So it's pretty windy.
0:39.3	And that's minus 1 degree Celsius. And it's gray.
0:44.4	Here in Chelsea, it's 5C and it feels like minus 3. You know, I always ignore the feels like.
0:51.3	But now since you said it, I'm going to say it, but I don't care what it feels
0:55.2	like. And it looks like it's, uh, it's windy here too. And it's, uh, a little bit of sun.
1:02.1	Kind of nice. You know, it's a day after Thanksgiving. So the, the trains are all full of people
1:06.2	who want to get deals, but there are no deals here in Manhattan. Sorry, folks. Go home and stop talking in the
1:14.3	quiet car. Sorry. Also joining us from Madison, New Jersey, Brianne Barker. Hi. It is great to be here.
1:24.3	It is four Celsius here and feels like minus 5, which my phone says is 39 and feels like
1:33.0	23 in Fahrenheit. Also gray, a good day to stay inside, avoid those crowds, and, you know, talk about
1:40.9	viruses. Yeah, it's just amazing how the conductors give up.
1:45.8	They don't even bother.
1:46.8	This is the quiet car.
1:47.8	This is the quiet.
1:48.4	They don't bother.
1:49.5	How can you tell a two-year-old to be quiet, right?
	...

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