TWiV 1265: mRNA vaccines make cancer treatment great again

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 26 October 2025

⏱️ 111 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV explains studies showing that SARS-CoV-2 mRNA vaccines improve life span of cancer patients on checkpoint immunotherapy, and broad immunity conferred by a vaccine central in A(H5) influenza antigenic space. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Immune 100 live at the Incubator SARS-CoV-2 mRNA vaccines sensitize tumors to checkpoint immunotherapy (Nature) People with some cancers live longer after mRNA vaccines (Nature) Immune checkpoint inhibitors (NCI) Broad immunity from influenza H5 vaccine (Nature) Derek Smith on antigenic cartography (TWiV 99 at 2:53) Letters read on TWiV 1265 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Kathy – Permethrin-treated baby wraps for malaria prevention and Phil Sharp and the Biotech Revolution Rich – Lydia Fairchild; Tetragametic Chimerism (NEJM) Alan – Warning Signs Vincent – radio.garden thanks to Kim! Listener Pick Jamie – SkyCards by Flightradar24 Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This week in Virology, the podcast about viruses, the kind that make you sick.
0:10.5	From MicrobTV, this is Twiv. This week in Virology, episode 1265, recorded in October 24th, 2025.
0:22.7	I'm Vincent Rackeniello, and you're listening to the podcast All About Viruses.
0:28.2	Joining me today from Ann Arbor, Michigan, Kathy Spindler.
0:32.0	Hi, everybody.
0:32.7	Oh, I forgot to pull up the weather, but it's kind of gray, and the weather is 50 degrees. Fahrenheit
0:41.6	feels like 42, and I can't do that Fahrenheit to conversion that quickly, but let's see what
0:48.8	it tells me here on a different app. Spinning, spinning, spinning, spinning.
0:55.1	Nine degrees.
0:57.5	Feels like seven Celsius.
1:00.8	Here in New York is 15.
1:02.9	C and cloudy feels like 11.
1:06.1	Also joining us from Austin, Texas.
1:07.0	Rich Condit.
1:08.9	Hi, everybody.
1:10.8	You know, I'm not sure what it is right now.
1:15.1	It's probably what my weather app tells me, which is 88 degrees, which is cool.
1:26.1	And it's going to rain tonight, they say. They're all liars, but... Cool. Right.
1:29.9	And it's going to rain tonight, they say.
1:33.2	They're all liars, but that's what they say.
1:34.3	That would be really welcome.
1:36.9	I haven't seen skywater for weeks.
	...

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