TWiV 1241: The most beautiful experiment

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 3 August 2025

⏱️ 117 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV reports the administration putting a choke hold on billions of NIH health research funding, US Senators tell scientists they want to protect the NIH budget, then review a classic experiment showing the mechanism of DNA replication, and explain how jumbo phage DNA is transcribed in a membrane-bound compartment before transfer into proteinaceous “nucleus” compartment. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, Jolene Ramsey, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV 5:13 Chokehold on billions in NIH funding (WSJ) Senators want to protect NIH budget (Nature) Replication of DNA in E. coli (PNAS) Biography of Franklin Stahl (DNA Learning Center) Franklin Stahl, 95 (Caltech Magazine) FW Stahl dies (NY Times) Requiem for a machine (Small Things Considered) Membrane and protein bound organelles during phage infection (Cell Host Micr) Letters read on TWiV 1241 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Benefits of interacting with Nature Brianne – “Why Trust Science” Essay Kathy – Dental floss delivery of vaccines to mice Rich – The Monk in the Garden Jolene – JWST COSMOS-Web Interactive Map viewer Vincent – New Injectable Recommended by Europe for HIV Prevention Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This Week in Virology, the podcast about viruses, the kind that make you sick.
0:10.4	From MicrobTV, this is Twiv. This week in Virology, episode 1241, recorded on August 1st, 2025.
0:23.1	I'm Vincent Rackeniello, and you're listening to the podcast All About Viruses.
0:28.4	Joining me today from Austin, Texas, Rich Condit.
0:33.3	Hi there, Vincent.
0:34.7	How you doing?
0:35.7	All right.
0:36.6	I haven't seen you in a while. No, I've been goofing off.
0:39.6	You've been in Bend. I've been in Bend, Oregon or nearby, and it's been very, very nice.
0:44.9	I got two kind of reboot from, believe it or not, being just too wound up in stuff, even though I'm
0:52.9	retired. This is crazy. But there you go. Actually, most of the stuff I'm wound up in stuff, even though I'm retired. This is crazy.
0:55.4	But there you go.
0:56.2	Actually, most of the stuff I'm wound up with has to do with singing, so I can't complain.
1:00.6	All right.
1:01.4	The weather here in Austin, Texas, is 100 degrees, 100-0-0 Fahrenheit.
1:08.6	And we have mostly blue skies, a few puffy clouds. That is normal for this time
1:14.2	a year, pretty much. And I'm not complaining because July was unusually mild. We had only one,
1:21.0	100 degree day. We've had only four, maybe five so far this season. So that's a break. And the reservoirs are full.
1:29.3	And I had a break in bend, so it's all good.
1:33.1	Here in Chelsea, New York, it is 23C.
1:37.4	After a month of 34, yesterday a thunderstorm rolled through, and that's it.
1:43.6	August 1st, boom, crap weather.
	...

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