TWiV 1239: Aluminum and antibodies

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 27 July 2025

⏱️ 111 minutes

🔗️ Recording | iTunes | RSS

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Summary

TWiV explains a cohort study of over one million Danish children which shows no evidence supporting an increased risk for autoimmune, atopic or allergic, or neurodevelopmental disorders associated with early childhood exposure to vaccines with aluminum-base adjuvants, and a study of antibodies induced by mRNA-1273 and NVX-CoV2373 COVID-19 vaccines which show that polyclonal antibodies against a single site on the spike N-terminal domain show immunodominance, high diversity, and limited cross-reactivity, indicating the need to direct antibody responses away from this site. Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV No chronic effects of aluminum-based adjuvants in vaccines (Ann Int Med) Aluminum in vaccines (CHOP) Structural serology of antibody responses to COVID vaccines (Cell Rep) Letters read on TWiV 1239 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Brianne – MHC Class I Antigen Presentation Video Alan – We Become What We Behold Vincent – New Injectable Recommended by Europe for HIV Prevention Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0	This week in Virology, the podcast about viruses, the kind that make you sick.
0:10.3	From ICOP TV, this is Twiv, this week in Virology. Episode 1239, recorded on July 25th, 2025.
0:22.2	I'm Vincent Rackeniello.
0:24.1	You're listening to the podcast, All About Viruses.
0:27.8	Joining me today from Western Massachusetts, Alan Dove.
0:31.6	Good to be here.
0:32.4	And it is, well, according to the weather service is 91 Fahrenheit 33C. My outdoor thermometer says 96 Fahrenheit, which is like 36C, something like that. So it's hot, muggy, and clouding over and looking like thunderstorms coming through.
0:53.2	Also joining us from Madison, New Jersey, Brian Barker.
0:57.1	Hi. It's great to be here. And it is also great to be indoors in the air conditioning.
1:03.3	It is currently 93 Fahrenheit. Very muggy. Also, we have severe thunderstorms that sounds like on their way.
1:13.8	Much better to be inside.
1:15.6	34C here in New York, Chelsea.
1:19.2	Yep, severe thunderstorm watch.
1:21.1	Just great.
1:22.6	Then the trains will be canceled.
1:24.7	Just great.
1:26.6	Oh, my gosh.
1:29.8	Well, the trains are not as bad as road traffic and a thunderstorm. The tracks flood and they don't want to drive on them. I don't know why.
1:36.0	I guess if it... Well, it's an electric train and if the tracks are underwater, you really don't want to do that.
1:41.6	But it's an overhead wire, so. Yeah, but...
1:44.7	So actually, my train is not electric because the line that I take from Newark is diesel.
1:52.9	Okay.
	...

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