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This Week in Virology

TWiV 1237: Hepatitis C and persistence with Charlie Rice

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.82.2K Ratings

🗓️ 20 July 2025

⏱️ 66 minutes

🧾️ Download transcript

Summary

From the 2025 annual meeting of the American Society for Virology, Charlie Rice, 2020 Nobel Laureate in Physiology or Medicine, talks with Vincent and Kathy about his career and the scientific difficulties he and his laboratory encountered in their attempts to achieve replication of hepatitis C virus in cells in culture. Hosts: Vincent Racaniello and Kathy Spindler Guest: Charlie Rice Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV 2020 Nobel Prize (Nobel Prizes) Hepatitis C human challenge study (Lancet Gastro Hepatol) Rat hepacivirus mouse model for hepatitis C (Hepatol) Replication of hepatitis C virus in cells in culture (Science) Lessons from domestication of HCV (Curr Opin Virol) Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

Transcript

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0:00.0

This week in Virology, the podcast about viruses, the kind that make you sick.

0:11.0

Hello, ASV!

0:17.0

From ASV 20, 25 in Montreal, Canada. This is Twiff, this weekend virology. Episode 1237,

0:30.0

1,237 episodes of real science. No lies, no misinformation, no disinformation, real science for you.

0:42.2

I'm Vincent Rackeniello, and you're listening to the podcast All About Viruses.

0:47.5

Today we are coming from ASV 2025. That's the American Society for Virology Annual Meeting in Montreal, Canada.

0:57.5

And joining me today here in Montreal, Kathy Spindler.

1:02.4

Hi, everybody. It's nice to be here. And I'll tell you a little bit about the weather.

1:06.5

There was some serious weather for about an hour and a half Sunday afternoon that messed up a lot of people getting here, including these two guys, but they're here now.

1:15.6

And then it's been as high as 90 Fahrenheit yesterday, which is 32 Celsius.

1:23.1

But today, it's one of my favorite temperatures.

1:26.4

It's 82 Fahrenheit, which is 28 Celsius.

1:30.2

Makes it easy for you. Remember, the palindrome, 82 is 28. And then for your interest, 16 is 61.

1:38.2

You've probably heard that before on Twith, but...

1:40.8

Does there any others?

1:43.0

That's it. Well, 42 or 43-ish, minus 42-minus-4-43-ish are about the same as each other.

1:48.9

Okay.

1:49.6

Yeah.

1:50.2

Our guest today is from the Rockefeller University in New York.

1:55.1

Charlie Rice, welcome.

1:57.1

Great to be here.

1:58.4

I think it.

...

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