TWiV 1048: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 30 September 2023

⏱️ 45 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses a molnupiravir-associated mutational signature in global SARS-CoV-2 genomes, inhaled fluticasone furoate for outpatient treatment of COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, early antibody treatment, inflammation, and risk of post-COVID conditions, autonomic dysregulation in long-term patients suffering from post-COVID-19 syndrome assessed by heart rate variability, and multiorgan MRI findings after hospitalization with COVID-19 in the UK. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Molnupiravir-associated mutational signature in global SARS-CoV-2 genomes (Nature) Inhaled fluticasone furoate for outpatient treatment of COVID-19 (NEJM) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Distinguishing features of Long COVID identified through immune profiling (Nature) Early antibody treatment, inflammation, and risk of post-COVID conditions (mBIO) Autonomic dysregulation in long-term patients suffering from post COVID-19 syndrome (SR) Multiorgan MRI findings after hospitalization with COVID-19 in the UK (The Lancet) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1048 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.4	From micro TV, this is TWIV, this week in virology, episode 1048, recorded on September 28th,
0:20.1	2023. I'm Vincent Racken Yellow, and you're listening to the podcast all about viruses.
0:27.2	Joining me today from New York, Daniel Griffin.
0:31.7	Hello, everyone. So Daniel, we're moving into October. What's the COVID situation now? Is
0:38.5	it still percolating? Was it moving up? Well, I'm going to be discussing a little bit about
0:44.6	wastewater and hospital admissions and giving people an update on where we are.
0:49.5	All right. So, yeah, so stay tuned, but let me start with my quotation.
0:56.0	This one's from Abraham Lincoln. My son, Barnaby, is writing his college essay, and so he
1:03.2	he was recounting a time we visited Abraham Lincoln's cottage on a rainy day. And so it got me
1:09.2	thinking about Lincoln, who has some some great words of wisdom. And here we go. Give me six hours
1:15.3	to chop down a tree, and I will spend the first four sharpening the axe.
1:20.4	Now, what does that mean, Daniel? You should have your tools ready.
1:24.4	I think it's the be prepared and where I'm going to sort of put it is, when you're going to do
1:30.0	research, when you're going to try to look into everything, don't just hit the road running,
1:35.4	prepare yourself, make sure you're going to do the research properly.
1:39.3	So Daniel, that means that if you want to look at infectious virus shedding, you shouldn't
1:44.4	just do PCR. If you're going to do the science, do it right. Take the time, get everything ready,
1:52.0	make sure you're asking the question properly, and then ask the question properly.
1:57.7	So let's start off with RSV. And for the last email that we read last week, this came in just
2:03.7	under the wire. I was actually watching because I, you know, we record Thursday night, and this
2:07.7	meeting was Friday. And so I'm hoping it goes. Otherwise, I'm going to quick call the Vincent, Vincent,
	...

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