TWiV 1040: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 2 September 2023

⏱️ 49 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-CoV-2 specific humoral and cellular immune responses after contralateral and ipsilateral COVID-19 vaccination, Pfizer and BioNTech receive positive CHMP opinion for Omicron XBB.1.5-adapted COVID-19 vaccine in the European Union, clinical antiviral efficacy of Remdesivir in COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, clinical outcomes associated with overestimation of oxygen saturation by pulse oximetry in patients hospitalized with COVID-19, risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination. Click arrow to play Download TWiV 1040 (19 MB .mp3, 27 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Public health significance of finding autochthonous melioidosis cases (PLOS) Human neural larva migrans caused by Ophidascaris robertsi ascarid (EID) Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics (HHS) Excess all-cause mortality in China after ending the zero COVID policy (JAMA) International pediatric COVID-19 severity over the course of the pandemic (JAMA) Differences in SARS-CoV-2 specific humoral and cellular immune responses after COVID-19 vaccination (eBioMedicine) Pfizer/BioNTech receive positive CHMP opinion for COVID-19 vaccine in the EU (Pfizer) Clinical antiviral efficacy of Remdesivir in COVID-19 (JID) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Clinical outcomes associated with overestimation of oxygen saturation in patients with COVID-19 (JAMA) Risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination (eClinicalMedicine) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1040 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.5	From microbe TV, this is TWIV, this week in virology. Episode 140 recorded on August 31st,
0:20.8	2023. I'm Vincent Racken Yellow and you're listening to the podcast all about viruses
0:28.1	joining me today from New York, Daniel Griffin. Hello, everyone. Last day of August, Daniel.
0:36.4	And the summer is wrapping up, so I'm going to start us with a quotation, a summer ending quotation.
0:44.3	What good is the warmth of summer without the cold of winter to give its sweetness,
0:49.2	and that's by John Steinbeck? Does that make you feel any better about summer ending, Vincent?
0:55.2	It doesn't bother me because as soon as it ends, it'll be back. That's how I look at it.
1:01.9	And I was listening to the Neil Diamond song, America Today, maybe give people some insight into
1:07.5	my musical listening. You know, but he was talking about coming to America and the warmth,
1:12.2	and I was like, I'm just hot. I don't want any more warmth, Neil.
1:15.2	So a little bit of a theme seems to be emerging over the last year. Lepercy, malaria,
1:23.3	dengue, West Nile virus, polio, all here in the US. And now the article, the public health
1:29.3	significance of finding autoxinous, milliodosis cases in the continental United States,
1:35.2	published in plus neglected diseases. So just some background, I'm people are familiar with this,
1:42.2	but milliodosis is an infectious disease caused by a Birkhold area pseudo-mallyi,
1:48.2	a bacterial pathogen that can infect humans and other animals. Human case in disease has been
1:53.5	thought to be restricted to Southeast Asia and northern Australia, where the pathogen is endemic,
1:59.2	found in the soil and water. But in recent years, the presence of Birkhold area pseudo-mallyi has
2:05.0	been demonstrated in the African and American continents, in the Caribbean islands as well as the
2:10.7	rest of Asia. And now, recently, the pathogen that causes milliodosis was found in the Gulf
2:18.2	Coast region of Mississippi, United States of America associated with human cases. I think we're
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