TWiV 1004: Clinical update with Dr. Daniel Griffin

This Week in Virology

Vincent Racaniello

Vincent, Microbe, Medicine, Microbiology, Racaniello, Infection, Virus, Virology, Pathogen, Infectious, Twiv, Science & Medicine

4.8 • 2.2K Ratings

🗓️ 6 May 2023

⏱️ 53 minutes

🔗️ Recording | iTunes | RSS

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Summary

In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among patients of family physicians in Canada, vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers than placebo, NVX-CoV2373 vaccine efficacy against hospitalization, comparative effectiveness of the SARS-COV-2 vaccines during Delta dominance, assessment of gender-specific COVID-19 case fatality risk per malignant neoplasm type, clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir among patients living in nursing homes, timing of intubation and ICU mortality in COVID-19 patients, real-life experience with Remdesivir for treatment of COVID-19 among older adults, and how long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA approves Arexvy, the first RSV vaccine approved in the US (FDA) Association between SARS-CoV-2 and content of samples from the Huanan Seafood Market (bioRxiv) Researchers disagree over how bad it is to be reinfected with COVID-19 and lasting changes to the immune system (Nature) Virtual care and emergency department use during the COVID-19 Pandemic among patients of family physicians (JAMA) Vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers (NEJM) NVX-CoV2373 vaccine efficacy against hospitalization (Vaccine) Comparative effectiveness of the SARS-COV-2 vaccines during Delta (Cell) Assessment of gender-specific COVID-19 case fatality risk (JAMA) Clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir (JAMA) Timing of intubation and ICU mortality in COVID-19 patients (BMC) Real-life experience with Remdesivir for treatment of COVID-19 (JAC) Long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA (Frontiers) Contribute to our FIMRC fundraiser at PWB Letters read on TWiV 1004 Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

Transcript

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0:00.0	This week in virology, the podcast about viruses, the kind that make you sick.
0:10.5	From micro.tv, this is TWIV, this week in virology, episode 1,000-4 recorded on May 4th, 2023.
0:22.0	I'm Vincent Rackenello and you're listening to the podcast all about viruses.
0:27.3	Joining me today from New York, Daniel Griffin. Hello everyone. We had a little discussion
0:33.6	last time about 1,000 episodes plus. Several people wrote in and said, you're not supposed to say
0:40.2	1,000 and four, you just say 1,000 four. Okay, did you know that? It's nice for the feedback.
0:48.8	Yeah, and also I'm supposed to put a comma in 1,000, which I do so. Oh, it's the guy that's
0:54.8	like to put the commas in, but I'll investigate. So let us get going. First off, today I am wearing my
1:02.4	coronavirus bow tie. You can see that there. Which coronavirus is it? You know, I'm sure it's
1:08.4	SARS-CoV-2. Now, this brings up an interesting thing. Now, I had this bow tie from before the
1:15.1	pandemic. I actually purchased it. I believe back in 2016. So here's the question, is it the same
1:20.8	spike protein? No, no, it's not. It's probably, it's just the coronavirus without any, it was a
1:29.0	generic, but it's different clearly. Doesn't have three pro-leens or two pro-leens either.
1:34.2	Okay, we'll start with the quotation. If a child is to keep alive, his inborn sense of wonder,
1:40.3	he needs the companionship of at least one adult who can share it, rediscovering with him the joy,
1:46.0	excitement, and mystery of the world we live in. And that's Rachel Carson. So you're my adult
1:51.7	friends, and I'm the child here. So we'll see why I start with this quotation in a minute. So
1:57.6	let's get right into RSV. This is very exciting. When I read this first bit of news, I did shout out
2:03.4	loud. Yes, finally. After 60 years, on May 3rd, the US Food and Drug Administration approved
2:11.7	our RSV, the first respiratory, sensational virus RSV vaccine for use in the United States.
2:18.5	So this is approved for prevention of lower breast-rate tract disease caused by RSV in individual
2:24.5	60 years of age and older. We discussed this before, actually discussed it last night with Cathy
	...

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