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Hey all, welcome back to the real life pharmacology podcast. I'm your host pharmacist,

Eric Christensen. Today we've got drugs 56 through 60 of the top 200 medications. Keep it on,

keep it on here. Let's get into it. So let's look at nitroferantoin.

Brand name of this medication is macrodenton or macrobid.

Mechanistically, this drug is altered by bacterial flava proteins and for reactive metabolites that disable ribosomal proteins

and other molecules within bacteria.

One of the most important things is UTIs is fairly common.

This is what this medication is used for.

UTIs are fairly common in geriatric patients, unfortunately. But we need to pay attention to renal function with this medication.

If renal function is too poor, this medication will not work and potentially can cause some toxicity issues as well there.

So there is some evidence, you know, package insert, I believe, says do not use less than 50 to 60 mils per minute.

Don't quote me on that 100%.

But as that creatin clearance, as that renal function declines, we got to get a little bit more

careful with this medication, like I mentioned.

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