Welcome to Rosam Franklin University College of Pharmacy Top 200 Drugs podcast.

This podcast is produced by the pharmacy faculty members to supplement study material for students learning the top 200 drugs.

We're hoping that our real-life clinical pearls and discussions

from practicing pharmacists will help you study for your next drug quiz. And now on to the show.

Welcome to Rosalind Franklin University's Top 200 Dr. Podcast, week four spring edition. I'm your co-host, Dr. Kane. And I'm Dr. Holmes. Podcast, week four, spring edition.

I'm your co-host, Dr. Kane.

And I'm Dr. Holmes.

And this week we're talking about atypical antipsychotics, some antidepressants,

and a few other agents as well.

So we'll go ahead and get started.

The first agent is bupropion, and it has two different brand names.

One is Welbutrin, the other is xyban.

So the two different brand names are used for two different indications. The brand name

whilebutrin is indicated for depression only and the brand name zyvan is indicated for smoking

cessation only. It's important to note that although this agent is approved for depression,

it is not approved for anxiety like our SSRIs and S-NRIs. And the reason for that is that it can

actually worsen anxiety. So the way that buproprion or wellbutrin or zybin or zybin works is that

it's a weak dopamine norepinephrine re-uptake inhibitor.

So we don't have the serotonergic re-uptake inhibition that we saw with SSRIs and S-NRIs.

Some of the adverse drug reactions that we look out for are CNS simulation, so this might translate

to insomnia, restlessness, or as mentioned previously, worsening of anxiety.

The medication is actually chemically similar to an amphetamine, which is why it can

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