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Short Wave

This Cellular Atlas Could Lead To Breakthroughs For Endometriosis Patients

Short Wave

NPR

Daily News, Nature, Life Sciences, Astronomy, Science, News

4.7 • 6K Ratings

🗓️ 19 July 2023

⏱️ 11 minutes

🧾️ Download transcript

Summary

For people with endometriosis—a mysterious disease where endometrial tissue grows outside of the uterus—medical visits can be especially frustrating. It takes some patients years (on average, ten years) to get a diagnosis and treatment options are limited. There are currently no cures. One researcher, Dr. Kate Lawrenson, is trying to change that. She and her team of researchers have created a cellular atlas of the disease and hope this cell-by-cell approach will open up doors for faster diagnosis options and better ways of managing it. In the meantime, she hopes that more people will learn about the disease in the first place.

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Transcript

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0:00.0

You're listening to shortwave from NPR.

0:07.8

So back when Kate Lawrenceon was a PhD student, she was enrolling patients for a study and

0:12.8

met someone who changed her life.

0:15.0

This patient was a woman in her early 30s and was in a lot of pelvic pain.

0:19.8

The patient didn't know why the pain was happening, but wanted a hysterectomy to remove

0:24.0

their uterus altogether.

0:26.0

She was having almost like menopausal symptoms, lots of sweating and just lots of, I'd say,

0:32.7

hormonal disruptions.

0:34.5

And I was just so struck by the fact that this person wasn't going to have the opportunity

0:38.5

to have a family if that's what they had wanted.

0:42.2

And it turned out the patient had endometriosis, a disorder Kate had never heard of before.

0:49.2

Endometriosis is when endometrial tissue, the tissue that makes up the inner lining

0:53.3

of the uterus grows outside the uterus on the ovaries or the fallopian tubes.

0:58.4

Or perhaps on the bowel or the bladder, but it can even be found at more distant locations.

1:03.4

And so we get people coming to our medical center who are having surgery for endometriosis

1:07.6

in the lungs.

1:08.6

And when the cells grow where they're not supposed to, there's no way for them to exit

1:12.8

the body as menstrual blood.

1:15.1

The cells become trapped, creating lesions.

1:18.0

Doctors and researchers group endometriosis into four different stages, minimal mild, moderate

1:22.8

and severe.

1:24.2

But these stages only describe the lesion size and location.

...

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