This Blood Test Reflects Muscle Quality, Lean Mass and Strength
High Intensity Health with Mike Mutzel, MS
Mike Mutzel
4.8 • 1.2K Ratings
🗓️ 26 July 2023
⏱️ 12 minutes
🧾️ Download transcript
Summary
Serum creatinine is an indicator of lean body mass and muscle quality, new studies find.
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Links to Studies, Images and Video: https://bit.ly/44D6Kce
Time Stamps:
00:00 Creatinine is independently associated with lean body mass, muscle strength, and muscle quality.
00:25 Serum creatinine is a marker of impaired kidney function.
00:40 Creatinine is a normal waste product of muscle metabolism.
00:50 Levels can be impacted by declining kidney function, inflammation, and blood pressure reduction medications.
01:00 Concentrations are impacted by age, sex, and body size.
01:30 Average muscle protein per kilo of body weight was higher in omnivores.
02:10 Serum creatinine is significantly lower in vegetarians.
03:00 There are statistically significant differences in hand grip strength between omnivores and vegetarians.
05:10 Creatinine levels over 1.4 mg/dl may be a marker of chronic kidney disease and poor kidney function.
06:00 Abnormal urinary creatinine to albumin ratio is a marker of kidney dysfunction.
07:05 Low serum creatinine can indicate acute illness, severe liver disease, loss of muscle mass, malnutrition, muscular dysfunction, dehydration, or sarcopenia.
07:30 Vegetarian diet, low body mass, and reduced strength are linked to low serum creatinine.
08:30 There is a correlation between quality of protein, quality of muscle tissue, and serum creatinine.
09:05 Omnivores have significantly greater dietary protein intake, serum creatinine levels, and grip strength.
09:45 Increasing protein above the RDA has beneficial effects on strength level in vegetarians.
Transcript
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| 0:00.0 | Let's talk about a novel biomarker for muscle quality and quantity. |
| 0:03.1 | I know many of you are focused on the importance of preserving lean muscle mass, |
| 0:06.1 | maintaining lean muscle mass and strength as you get older. |
| 0:08.9 | Today, we're going to talk about serum creatinine and how that is |
| 0:11.9 | independently associated with lean body mass, muscle strength, and muscle quality. |
| 0:16.0 | I want to share with you this paper here. |
| 0:18.0 | See him creatinine as an indicator of lean body mass in vegetarians and omnivores. |
| 0:21.9 | And this was published in the Journal of Frontiers in Nutrition in September of 2022. |
| 0:26.1 | So normally, serum creatinine is a marker of impaired kidney function. |
| 0:30.4 | Kidney disease, chronic kidney disease. |
| 0:31.8 | When it's elevated over 1.5 milligrams per deciliter, |
| 0:34.8 | that would indicate some sort of kidney failure. |
| 0:37.0 | But besides that, most clinicians are not looking at serum creatinine |
| 0:40.4 | to approximate your lean body mass and your muscle quality. |
| 0:43.0 | But since serum creatinine is a normal waste product of muscle metabolism, |
| 0:47.6 | it is a reliable biomarker for muscle mass, |
| 0:50.4 | since it's continually produced and filtered through the kidneys. |
| 0:53.3 | However, many factors can impact serum creatinine levels of scientists, |
| 0:56.4 | say most notably declining kidney function, |
| 0:59.0 | as well as pro-inflammatory markers, |
| 1:01.1 | and blood pressure reduction medications, and the like. |
| 1:04.0 | But serum creatinine is generated from muscle again. |
... |
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