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The Dr. Gabrielle Lyon Show

The Truth About Women’s Metabolism, Muscle & Fat Loss at Every Age | Abbie Smith-Ryan, PhD

The Dr. Gabrielle Lyon Show

Dr. Gabrielle Lyon

Medicine, Science, Health & Fitness, Life Sciences

4.6911 Ratings

🗓️ 6 May 2025

⏱️ 85 minutes

🧾️ Download transcript

Summary

In this episode, I’m joined by Dr. Abbie Smith-Ryan—one of the leading researchers in exercise physiology and women’s metabolism—to unpack the science of how women should be training through perimenopause, postmenopause, and beyond. We dive into the physiological changes that impact body composition, performance, and recovery—and how to adjust training and nutrition to match.

We discuss:

  • How high-intensity interval training (HIIT) improves VO₂ max, fat oxidation, and muscle quality in women
  • Whether fasted training helps or hurts, and why so many women are under-fueled
  • What the science really says about lifting heavy and building muscle over 40
  • Nutrient timing, rest intervals, and why sex-based differences in physiology matter
  • What we still don’t know about hormone therapy, protein needs, and female-specific adaptations

If you’re navigating training, muscle loss, or metabolic changes through midlife, this conversation will give you clarity, confidence, and evidence-based strategies you can actually use.

Who is Dr. Abbie Smith-Ryan?

Dr. Abbie Smith-Ryan is a leading expert in exercise physiology and sports nutrition, currently serving as Associate Chair for Research and Director of the Applied Physiology Lab at the University of North Carolina at Chapel Hill. Her research focuses on evidence-based exercise and nutrition strategies to improve body composition, cardiovascular health, and metabolic function—particularly in women, perimenopausal and postmenopausal populations, and those with obesity. She has authored over 200 peer-reviewed publications and led numerous NIH- and industry-funded clinical trials. Recognized as a top scientist in her field, Dr. Smith-Ryan is also a dedicated educator and mentor, passionate about translating science into actionable strategies that enhance health and performance.

This episode is brought to you by:


Find Dr. Abbie Smith-Ryan at:

  • Website - https://asmithryan.com/
  • Instagram - https://www.instagram.com/asmithryan/
  • LinkedIn - https://www.linkedin.com/in/abbiesmithphd/

Find me at:

Transcript

Click on a timestamp to play from that location

0:00.0

Has anyone ever told you you lived like a girl?

0:03.0

Probably not, but that doesn't stop people from saying,

0:06.0

you should lift a certain way because you're a woman.

0:09.0

But is that actually true, or is that just another myth

0:13.0

holding women back from reaching their full potential?

0:16.0

Today, we're diving deep into the science of women's metabolism,

0:20.0

strength, and longevity longevity with one of the

0:22.4

top researchers in exercise physiology and nutrition. Dr. Abby Smith Ryan will break down the

0:29.3

real differences between men and women when it comes to training, whether cycle-based workouts

0:35.4

actually matter and the biggest mistakes women make when it comes to fitness and health.

0:41.3

The data was showing us that between kind of late 30s and into 40s, there's this pretty big change in body composition and both physical and mental health.

0:53.3

And so we're really trying to understand

0:56.0

some of the things that are happening in that space. So if you've ever wondered whether you

1:00.5

should be training differently or eating differently or more protein, if your hormones really are

1:07.5

to blame, then this episode is for you.

1:17.3

Dr. Abby Smith-Ryan, welcome to the show.

1:18.8

Thanks so much for having me.

1:20.7

And on a Sunday, no less.

1:23.5

So thank you for all your time.

1:25.4

Yeah, I can't believe we made it happen.

1:26.3

So appreciate the time.

1:28.3

Yes, and hopefully not the last time. we make it happen. That would be great.

...

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