The Truth About Nutrient Deficiencies NO ONE Talks About + Improving REM & Deep Sleep Scores | Dr. Ralph Esposito, Chief Science Officer at AG1
The Art of Being Well
Dear Media, Will Cole
4.7 • 1.2K Ratings
🗓️ 1 December 2025
⏱️ 85 minutes
🧾️ Download transcript
Summary
In this episode, Dr. Will Cole sits down with Dr. Ralph Esposito, Chief Science Officer at AG1, to talk about what’s really missing from most people’s nutrition - and how precision health is changing the future of wellness. They dive into the science behind nutrient deficiencies, the truth about supplement research, and how food, stress, and lifestyle shape bioavailability and long-term health. Dr. Esposito also reveals exclusive research on AG1’s new NextGen and AGZ formulas, the problem with outdated nutrient recommendations, and how AI and metabolomics are redefining functional nutrition. For all links mentioned in this episode, visit www.drwillcole.com/podcast.
AG1 has their best offer ever - If you head to DrinkAG1.com/willcole you’ll get the welcome kit, a free bottle of Omega 3's, free bottle of Vitamin D3+K2, all 3 AG1 Flavor Sampler and you’ll get to try their new sleep supplement AGZ in all 3 flavors for free - which has been a game changer for my nightly routine. That’s $126 in free gifts for new AG1 subscribers!
Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.
Sponsors:
- AG1 has their best offer ever - If you head to DrinkAG1.com/willcole you’ll get the welcome kit, a free bottle of Omega 3's, free bottle of Vitamin D3+K2, all 3 AG1 Flavor Sampler and you’ll get to try their new sleep supplement AGZ in all 3 flavors for free - which has been a game changer for my nightly routine. That’s $126 in free gifts for new AG1 subscribers!
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Transcript
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| 0:00.0 | The following podcast is a Dear Media production. Hi, it's Dr. Will Cole. This podcast is the manifesto for a new breed of health seekers. This is the art of Being Well. |
| 0:28.5 | What's up and welcome to The Art of Being Well? |
| 0:34.6 | In addition to having two new episodes of The Art of Being Well, every week for you, I have at least one, sometimes two, new articles at Dr. Wilcold.com. |
| 0:41.3 | Again, my goal here is to make functional medicine, resources, protocols, tools, accessible, |
| 0:47.8 | and affordable, and all of this stuff is completely free. Obviously, the podcast is free, |
| 0:51.9 | and the articles at Dr. Wilcolde.com and go through the link to PubMed, |
| 0:57.2 | all the research. |
| 0:58.0 | You can kind of see the exciting research in human health, human nutrition, and in functional |
| 1:02.8 | medicine. |
| 1:03.5 | Some of the more recent articles at the time of recording this is great natural remedies for |
| 1:07.9 | psoriasis relief, an article about EMDR, |
| 1:11.5 | there's eye movement, desensitization, and reprocessing, |
| 1:14.1 | and type of therapy that we see great success for our nervous system regulation for our telehealth patients. |
| 1:19.1 | Another article about magnesium and the different types of magnesium out there |
| 1:22.4 | and which ones I like best that move the needle on telehealth patient labs. |
| 1:27.4 | So, again, you can learn more about all of that stuff at Dr. |
| 1:30.1 | Wilcoel.com and DRWI-L-C-O-L-E.com. |
| 1:35.3 | All right, let's get to today's guest. |
| 1:37.7 | Longtime friend of mine, his name is Dr. Ralph Esposito. |
| 1:41.3 | He was on the pod actually a few years ago, but we get into a completely different |
| 1:45.6 | conversation today. You're all going to love it. Dr. Ralph Esposito is the chief science officer |
| 1:50.6 | at AG1 to explore what most people get wrong about nutrition and supplementation. We discuss |
... |
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