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The Uncertain Hour

The sentence that helped set off the opioid crisis

The Uncertain Hour

Marketplace

Government, News

4.82.2K Ratings

🗓️ 13 December 2017

⏱️ 66 minutes

🧾️ Download transcript

Summary

When OxyContin went to market in 1996, sales reps from Purdue Pharma hit one point particularly hard: Compared to other prescription opioids, this new painkiller was believed to be less likely to be addictive or abused.

But recently unsealed documents in this investigative episode shed light on how the maker of OxyContin seems to have relied more on focus groups than on scientific studies to create an aggressive and misleading marketing campaign that helped fuel the national opioid crisis.

Welcome back to The Uncertain Hour. Where the things we fight the most about are the things we know the least about. Subscribe on your favorite podcast app.

Transcript

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0:00.0

Whether you're doing a dance to your favorite artist in the office parking lot,

0:04.0

or being guided into Warrior I in the break room before your shift,

0:08.0

whether you're running on your Peloton tread at your mom's house while she watches the baby,

0:13.5

or counting your breaths on the subway.

0:18.9

Peloton is for all of us, wherever we are whenever we need it. Download the free Peloton app today.

0:25.3

Peloton app available through free tier or pay to description starting at 1299 per month.

0:30.2

So when you get a prescription drug at the pharmacy, it comes in a box or a bottle,

0:35.8

and maybe you've noticed that you also get this little package insert that comes with it.

0:40.8

Often it's this very long folded up piece of paper in very small print,

0:46.4

with a lot of medical and scientific jargon in it, information about clinical studies,

0:52.0

dosing, side effects. Maybe you've tried to read one of these in a prescription you've gotten.

0:57.4

Maybe you've given up. They're pretty dense. In the pharmaceutical world,

1:02.0

this package insert is referred to as the label, not to be confused with that little sticker on the

1:07.4

bottle that you or I might call the label, but this jargon-y package insert. And I'm holding in my

1:14.5

hands one of these package inserts, one of these labels. It's one you can't find at a pharmacy anymore.

1:21.4

The label I'm looking at right now is the original label from 1995 for OxyContin,

1:27.5

you know, the painkiller. It's produced by Purdue Farma. OxyContin was approved by government

1:33.7

regulators at the Food and Drug Administration in 1995, and part of that approval process

1:39.9

involved approving the words on this label. The label's really long, 21 pages, but on page 15,

1:49.3

under the Drug Abuse and Dependence section, there's this one sentence.

2:02.0

It's a mouthful, so I'll read it to you again. Delayed absorption, as provided by OxyContin

2:09.7

is believed to reduce the abuse liability of a drug. Remember that sentence. It arguably helped

...

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