4.8 • 729 Ratings
🗓️ 14 October 2025
⏱️ 41 minutes
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Prof. Keith Kozminski explores the plasma membrane’s evolving scientific understanding, highlighting its role as both boundary and bridge in cellular life through detailed analysis of structure, function, and paradigm shifts in biology.
This lecture was given on July 19th, 2025, at Dominican House of Studies.
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About the Speakers:
Keith Kozminski is an Associate Professor of Biology and Cell Biology at the University of Virginia, where he studies polarized cell growth, in particular the role of lipid transfer proteins in intracellular membrane trafficking and secretion. In addition, he conducts research in the field of synthetic biology, as applied to health and environmental sustainability. He leads the Mid-Atlantic Synthetic Biology Network comprised of academic, private sector, and government researchers from Georgia to Delaware, in addition to being the senior Features editor of Molecular Biology of the Cell, the research journal of the American Society of Cell Biology. He also co-founded the biotech company Ourobio in 2020.
Keywords: Abbe’s Resolution Limit, Cell Biology, Compartmentalized Fluid Model, Electron Microscopy, Gordon Grendel Experiment, Lipid Bilayers, Membrane Transport, Phospholipids, Protein Structure, Singer Nicholson Model
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| 0:21.5 | to mystic institute.org. So I chose as a topic of plasma membrane because it really |
| 0:28.6 | checks all those boxes. And the plasma membrane, the cell membrane, that edge of the cell, |
| 0:35.5 | that distinguishes or is the boundary between inside the cell |
| 0:39.7 | and outside the cell is not a new topic for cell biologists at all. It was first named |
| 0:46.6 | by Carl Magley back in 1855. The concept of the cell as the unit of life actually predated that by at least 15 years. |
| 1:00.0 | And if you press history more, you can say that idea was even emerging in the second half of the 18th century. |
| 1:09.9 | With that, there's been a lot of study of the cell membrane, |
| 1:14.0 | the plasma membrane. It's been a rocky road. There's been many ideas put on the table in |
| 1:22.0 | terms of its function and its structure, and those ideas over the past 170 years have changed. |
| 1:30.6 | And sometimes the change has been quite abrupt. |
| 1:34.9 | And I want to give some examples of that. |
| 1:37.7 | So we're going to see a little cell biology mixed with history as well. |
| 1:41.6 | I think that's a condition of my undergraduate time being a history major. |
| 1:48.5 | Okay, so before I talk about what is the plasma membrane, also known as the cell membrane, |
| 1:56.1 | what it's composed of, I want to talk about its function. |
| 2:00.6 | And really its function is that of a boundary. |
| 2:05.5 | Again, between outside world and inside world, and I'm going to start my timer, so I don't talk |
| 2:13.1 | for two hours. But it's a specialized boundary. And we can think of more functions than just |
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