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Finding Genius Podcast

The Nose Knows: Disease-Sniffing Dogs (and Humans?)

Finding Genius Podcast

Richard Jacobs

Health, Extracellularvesicles, Crisprcas9, 3dbioprinting, Medicine, Cancer, Health & Fitness, Biotech, Bioscience, Microbiome, Ketogenicdiets

4.41K Ratings

🗓️ 12 April 2021

⏱️ 27 minutes

🧾️ Download transcript

Summary

Can you smell disease? Believe it or not, you can, and pretty reliably at that. The problem is, you aren’t good at describing and quantifying what you smell, and definitely not at “diagnosing.” Aromyx is a company that’s doing something incredibly unique to circumvent this problem, while utilizing scent detection for all it’s worth.

Press play to learn:

  • How “smelling” something is actually an act of detecting distinct chemical metabolite signatures from tissues in the body
  • By what percentage dogs have been shown to more accurately and sensitively detect prostate cancer than the status quo, FDA-approved test
  • How the olfactory system could eventually hold the key to therapeutics for a range of diseases

Olfaction (the sense of smell) has been used for hundreds of years to detect disease—even the ancient Greeks practiced it. Josh Silverman is the CEO of Aromyx, a company that’s taking full advantage of this powerful sense.

So, how are they doing it?

By developing validated clinical assays for diagnosing disease states, using the same scent and taste receptors that are in your nose and tongue. By cloning those receptors and putting them in a format that be used in the lab to measure responses from individual receptors, Aromyx is effectively hijacking the same information that goes from your nose to your brain when you smell or taste something, and putting it in an objective, readable, and quantifiable format.

They’re taking a powerful “subjective” experience, and making it a powerful objective measurement of chemical metabolites which indicate the presence of certain diseases. And, the level of detection is orders of magnitude beyond any electronic sensors or other technology currently in existence.

So far, Aromyx has used this technology to detect prostate cancer, pancreatic cancer, and malaria, and they know that the potential for much wider diagnostic capabilities is well within reach.

Silverman dives into all the details of this and more.

Tune in, and check out https://www.aromyx.com/ to learn more.

Episode also available on Apple Podcasts: apple.co/30PvU9C

Transcript

Click on a timestamp to play from that location

0:00.0

Forget frequently as questions.

0:02.0

Common sense, common knowledge, or Google.

0:05.0

How about advice from a real genius?

0:07.0

95% of people in any profession are good enough to be qualified in license.

0:11.0

5%?

0:12.0

Go above and beyond.

0:13.0

They become very good at what they do.

0:15.0

But only 0.1% are real geniuses.

0:18.0

Richard Jacobs has made his life's mission to find them for you.

0:22.0

He hunts down and interviews geniuses in every field.

0:25.0

Sleep science, cancer, stem cells, ketogenic diets, and more.

0:29.0

Come the geniuses.

0:30.0

This is the Finding Genius Podcast.

0:33.0

The Richard Jacobs.

0:36.0

Quick note before we begin.

0:39.0

The Finding Genius Foundation, as part of the Finding Genius Podcast,

0:42.0

has recently completed a book about understanding viruses.

0:46.0

So the creation of this book was to interview 100 virologists,

0:50.0

ask them a lot of deep difficult questions, take the most difficult questions,

0:54.0

and then re-interview the top 25 or so,

0:57.0

and ask them the hardest questions I could think of.

1:00.0

And we compile that all into a book.

...

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