The Long-Known Vesicle Bringing Brand New Insights on Epigenetic Inheritance and Disease Processes—Denis Noble—Biologist and Contributing Author of Exosomes in Health and Disease
Finding Genius Podcast
Richard Jacobs
4.4 • 1K Ratings
🗓️ 10 January 2019
⏱️ 73 minutes
🧾️ Download transcript
Summary
Just around the corner is the publication of Exosomes in Health and Disease, an enormous compilation of data on exosomes and their role in almost every disease you can imagine. What's an exosome, you might ask? At just a fraction of the size of even the smallest bacteria, exosomes are tiny vesicles communicating with and carrying information to cells anywhere in the body. We've known about them for decades, but a recent discovery holds huge implications for our understanding of epigenetics, epigenetic inheritance, and the causes of diseases.
Denis Noble, physiologist, researcher, and former Chair of Cardiovascular Physiology at the University of Oxford joins the podcast today to offer a fascinating conversation about the presence of epigenetic data within exosomes, their ability to control the genome of other cells by simply communicating with them, and the profile components that could indicate cancer or a particular disease state.
He also discusses the techniques used to extract such small vesicles from blood plasma and the challenges that this process has brought about, the transmission of epigenetic information by exosomes through the germline, symbiogenesis, and more.
Tune in for all the details.
Transcript
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| 0:00.0 | You're listening to the Future Tech Podcast with Richard Jacobs. |
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| 0:58.0 | Thank you. My guest today is Dennis Noble. He's a British biologist who held the |
| 1:09.2 | burden Sanderson chair of Cardiovascular Physiology at the University of Oxford from 1984 to 2004. |
| 1:16.1 | He was appointed Professor Emeritus and co-director of Computational Physiology. |
| 1:20.8 | He's one of the pioneers of systems biology and developed the first viable mathematical |
| 1:26.2 | model of the working part in 1960. |
| 1:29.8 | His background is so extensive, I can't really give it justice but I can give a few more |
| 1:36.0 | tidbits. He's published over 600 articles in academic journals such as |
| 1:41.4 | Nature Science, PNAS, the Journal of Physiology, |
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