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🗓️ 1 September 2025
⏱️ 27 minutes
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What does it take to earn the nickname, ‘The Leonardo da Vinci of heart surgery’?
That's the moniker given to today's guest - a man who pioneered high-profile and often controversial procedures, but also helped drive huge medical progress; carrying out around 2,000 heart transplants and 400 dual heart-lung transplants during his 60-year career.
Sir Magdi Yacoub is Emeritus Professor of Cardiothoracic Surgery at Imperial College London, and Director of Research at Harefield Hospital’s Magdi Yacoub Institute. Inspired by a surgeon father and impacted by the tragic early death of his aunt from a heart condition, his medical career includes various surgical firsts alongside numerous research projects, to further our understanding of and ability to treat heart disease. He headed up the teams that discovered it is possible to reverse heart failure, and that successfully grew part of a human heart valve from stem cells for the first time.
But it hasn't always been plain sailing. At times, his work – such as early, unsuccessful transplant attempts, or using a baboon as a life-support system for a baby – attracted serious public criticism.
Speaking to Professor Jim Al-Khalili, Sir Magdi reflects on the highs and lows of his cardio career, and offers his advice to the next generation of surgeons and researchers hoping to make their mark in heart medicine.
Presented by Jim Al-Khalili Produced by Lucy Taylor Reversion for World Service by Minnie Harrop
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| 0:00.0 | I'm Rory Stewart and I grew up wanting to be a hero and I'm still fascinated by the ideas of heroism. |
| 0:08.9 | In my new series, I'm taking in the long sweep of history from Achilles to Zelensky and asking, what is a hero? |
| 0:16.2 | Simply doing your job, being a decent human being. |
| 0:20.0 | A true hero is someone who just kind of shines by |
| 0:23.1 | their own light and that light is to be recognised by others. The long history of heroism with me, |
| 0:28.6 | Rory Stewart. Listen on BBC Sounds. My guest today is quite simply one of the world's |
| 0:34.6 | best known and most prolific heart surgeons, a man who pioneered |
| 0:39.1 | high profile and often controversial procedures, but whose help drive huge medical progress. |
| 0:45.7 | Sir Magdiakoub is Emeritus Professor of Cardiothoracic Surgery, so that's Heart and Lungs, |
| 0:51.9 | at Imperial College London, and Director of Research at Harefield Hospital's Magdi Yakub Institute. |
| 0:58.5 | Inspired by a surgeon father and impacted by the tragic early death of his aunt from a heart condition, |
| 1:04.5 | Sir Magdi's medical career has deeply personal roots. |
| 1:07.7 | And alongside surgery, he's led numerous research projects to further our understanding |
| 1:12.0 | of and ability to treat heart disease. Over a career spanning more than six decades, |
| 1:18.5 | Magde's carried out around 2,000 heart transplants, earning him the moniker the Leonardo |
| 1:23.8 | da Vinci of heart surgery. But at times his work, such as early unsuccessful transplant |
| 1:29.7 | attempts, attracted serious public criticism, not an easy thing for anyone to weather. Today, of course, |
| 1:36.0 | the transplant landscape is very different, thanks in no small part to Magli himself. And, as he puts |
| 1:41.6 | it, science progresses by imaginative leaps. The only way is to keep |
| 1:46.5 | pushing forward. Professor Sambagdiakou, welcome to the Life Scientific. Thank you very much. |
| 1:51.8 | I alluded there to the controversy around heart transplants when they were first trialed. |
| 1:56.5 | What was it, do you think, that made this such a controversial issue for some when others, including you, saw it as the future? |
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