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NutritionFacts.org Video Podcast

The Benefits of Saffron for Treating Age-Related Macular Degeneration

NutritionFacts.org Video Podcast

Michael Greger, M.D. FACLM

Alternative Health, Nutrition, Health & Fitness

4.8952 Ratings

🗓️ 10 March 2025

⏱️ 5 minutes

🧾️ Download transcript

Summary

Eight threads of saffron a day can improve visual acuity in older adults with mild or moderate age-related macular degeneration.

Transcript

Click on a timestamp to play from that location

0:00.0

In addition to two to three daily servings of green leafy vegetables, berries are considered

0:12.0

a healthy choice for the preservation of eye health.

0:16.0

As we age, our critical retinal pigment epithelium layer starts to break down. However, we may be able

0:22.4

to decelerate that aging with blueberries. Human RPE cells bathed in blueberry anthesinousin

0:28.8

had fewer free radicals in a lower proportion of aged cells, suggesting that blueberries and other

0:33.4

red, blue, and purple pigmented fruits and vegetables may help prevent age-related macular

0:38.7

degeneration. Protective properties have also been demonstrated in vitro on RPE cells from

0:44.7

purple sweet potato anthocyanin, as well as the yellow pigment in turmeric and an amla extract,

0:51.8

Indian gooseberry. However, the only human interventional trials on berries for vision were a month-long trial

0:59.0

of a bilberry extract that demonstrated significantly less eye strain after iPad use compared

1:05.0

to placebo, and a study showing three weeks of blueberry juice or freeze-dry blueberry powder,

1:10.0

both significantly improved

1:11.6

photostress recovery time, which is a time needed to recuperate visual acuity after bright light

1:17.8

exposure by about five seconds. Only one pigmented food has been put to the test in macular

1:23.6

degeneration patients, though the spice saffron. Saffron is so potent that the whole spice can be stuffed into capsules to pit them head-to-head

1:32.3

against placebo.

1:34.3

Those with early stage age-related macular degeneration were randomized to a tiny pinch,

1:39.3

20 milligrams, about eight threads of saffron versus placebo for three months.

1:48.3

Compared to the placebo group, the saffron group experienced a significant improvement in retinal flicker sensitivity.

1:50.9

That's our ability to pick out high-frequency light pulses rather than seeing the flickering

1:55.0

light as a steady beam that diminishes with age.

1:58.6

It's a sensitive test of retinal function, but is of questionable clinical value.

...

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