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All-In with Chamath, Jason, Sacks & Friedberg

Supercharging a New FDA: Marty Makary on Science, Power & Patients

All-In with Chamath, Jason, Sacks & Friedberg

All-In Podcast, LLC

Technology, Entrepreneurship, Business

4.010.4K Ratings

🗓️ 15 January 2026

⏱️ 90 minutes

🧾️ Download transcript

Summary

(0:00) Friedberg intros FDA Commissioner Marty Makary

(3:21) Inside the 42 major FDA reforms in 10 months

(7:51) The China Race: Winning back biotech leadership

(13:14) Accelerating drug approvals safely, how to cut down on clinical trial timelines

(33:13) Reshaping the failed Food Pyramid

(41:29) GLP-1s and America's Obesity Epidemic

(49:54) Rethinking vaccines from first principles

(59:40) Lowering drug prices, the power of AI for healthcare

(1:18:57) What causes autism?

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Intro Music Credit:

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Intro Video Credit:

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Transcript

Click on a timestamp to play from that location

0:00.0

Marty McCarrie, Commissioner of the FDA. Welcome to San Francisco.

0:03.6

Great to be here, Dave. Good to be with you.

0:05.1

Yeah, thanks. It's J.P. Morgan Healthcare Conference this week in San Francisco

0:08.7

considered, I think, probably the biggest, most important biotech conference globally.

0:14.3

Very important week. So you're visiting this week for the conference?

0:17.8

Yeah. 120,000 people. Great conversations you hear from everybody. Just not enough time to meet with everybody you want to meet with, but it's a great time. Well, thanks for sitting down with me. You and I have gotten to know each other a little bit over the last year or so. Yeah. And I'm really excited to hear a little bit about how things are going. It's been almost a year since you've been in the role. I think maybe for our audience, you could share a little bit about how you got this role.

0:43.0

How did you get involved with this administration? How did you get connected with them? And maybe

0:46.4

we can go all the way back to your very outspoken views during the COVID pandemic.

0:51.3

And maybe how that brought attention to you and your philosophies that

0:54.7

drove this role. Yeah, so my interest in academia, I went to graduate school for public health

1:01.9

and served on the faculty of the Johns Hopkins School of Public Health, as I also had a clinical

1:07.1

practice in GI and cancer surgery at Johns Hopkins.

1:11.6

And my interest was always in the root causes of our healthcare system problems, from quality,

1:18.6

transparency, and price.

1:20.6

And in the work on price, I led sort of a national effort to try to get more price transparency

1:27.0

of hospital prices.

1:28.9

I wrote a book on it that did very well. It took me to the White House where they had read the book,

1:33.7

invited me in, and in that first Trump administration, we had a lot of great conversations.

1:38.3

And then they implemented the idea. And I was so impressed, this makes sense,

1:42.3

you know, we want common sense ideas. And so we got the hospital price transparency executive order signed by the president.

1:49.0

That's where I developed some of the relationships and got to know the folks.

1:53.0

And then when President Trump got reelected, he gave me a call days after the election.

...

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