Study Reveals NEW Hormone LEAP2 Behind How High Protein Diets Generate Ketones & Appetite Supression

Optimal Protein Podcast with Vanessa Spina

Vanessa Spina

Fitness, Health & Fitness, Nutrition

4.5 • 758 Ratings

🗓️ 14 February 2025

⏱️ 46 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

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In today’s episode of The Optimal Protein Podcast, we uncover a groundbreaking discovery about LEAP2, a newly identified hormone that plays a key role in hunger regulation, ketone production, and appetite suppression.

We are breaking down a 2022 study published in Endocrinology titled b-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2 (PubMed link).

This research reveals how ketones specifically b-hydroxybutyrate (BHB) interact with LEAP2 and the hunger hormone ghrelin, explaining why high-protein, low-carb, and ketogenic diets naturally reduce appetite and support fat loss.

If you’ve ever wondered why a high-protein diet helps you stay full longer while promoting fat-burning, this episode explains the new science behind it!

Key Takeaways

-What is LEAP2? The newly discovered hormone that regulates hunger and ketone metabolism.

-How high-protein diets generate ketones, even without high fat intake.

-The role of BHB in appetite suppression.

-How LEAP2 interacts with ghrelin, the hunger hormone.

-Why hunger may temporarily increase when starting ketosis but decrease over time.

-How this research explains the long-term appetite-suppressing effects of ketogenic and high-protein diets.

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Follow @ketogenicgirl for updates on the latest studies and strategies to optimize protein intake and metabolic health.

Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.

Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/

The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Transcript

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0:00.0	Welcome to the Optimal Protein Podcast. I'm Vanessa Spina.
0:05.5	Hello, my friends. Welcome back to the podcast. I'm your host, Vanessa, and I am so excited for today's
0:11.4	episode. We are breaking down a recent study that is all about how high protein diets actually
0:19.1	suppress appetite. And we're also going to be talking about the role of ketones and how high protein diets actually suppress appetite. And we're also going to be talking about the role of ketones and how high protein diets
0:25.8	actually generate ketones, especially when they are low carb, and how this actually is one of
0:33.8	the surprising mechanisms behind why high protein diets induce so much satiety. So I'm
0:41.1	really excited to break down this recent study with you all. There's a couple of other studies as
0:46.5	well that explore this concept and mechanisms. So there's a few in there that we're going to be
0:52.2	breaking down and really exploring this fascinating research on how high protein diets work, why they are so effective, especially for people seeking fat loss, weight loss, body recomposition because of their incredibly powerful effect on appetite suppression. And we're going to talk
1:12.8	about how exactly that works and why doing a high protein lower carb approach can be so extremely
1:21.7	effective. So really excited to break down these studies with you all in this episode today.
1:27.0	And we will jump
1:28.2	right in after this quick break. Friends, I have to share with you an incredible anti-aging
1:34.3	secret that I have now become obsessed with. Now, you've probably heard that aging is actually
1:40.1	caused by free radical damage. Now, this damage is a byproduct of creating cellular energy
1:46.0	inside our cells at the mitochondrial level. So by providing our mitochondria with antioxidants,
1:53.0	we can actually prevent a lot of that damage from happening in the first place.
1:58.0	There are only four antioxidants that can actually get inside the inner membrane
2:02.8	of the mitochondria, and that includes glutathione, chlorilla, and something called superoxide
2:09.8	dysmutease, as well as melatonin. Now, after the age of 30, the levels that our bodies make for us
2:16.8	fall off a cliff.
2:18.2	And this is why aging accelerates and health issues start to pop up.
	...

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