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Short Wave

Stopping SSRIs Can Be Hard. Researchers Are Unsure Why

Short Wave

NPR

Daily News, Nature, Life Sciences, Astronomy, Science, News

4.76K Ratings

🗓️ 2 September 2025

⏱️ 14 minutes

🧾️ Download transcript

Summary

More than 1 in 10 people in the United States take an antidepressant. And the most commonly prescribed type of antidepressant are SSRIs — or selective serotonin reuptake inhibitors. That includes drugs like Zoloft, Prozac and Lexapro. But what happens when some patients decide they want to stop taking their SSRIs? While doctors know stopping SSRIs can sometimes cause unpleasant short-term side effects – like dizziness, anxiety, insomnia and nausea – some people report symptoms that last months, even years. So, with investigative reporter Emily Corwin and professor of clinical psychology Michael Hengartner, we’re diving into the research around the long-term effects of going off your antidepressants – what it shows and its limits. 


Read more of Emily Corwin’s reporting on the topic here


Want more stories on mental health? Email us at [email protected].


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Transcript

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0:00.0

This message comes from Rethinking, a podcast from TED.

0:03.5

On Rethinking, organizational psychologist Adam Grant talks to today's greatest minds

0:08.5

about the ideas you might take for granted and what assumptions you should reconsider.

0:13.2

Find Rethinking wherever you listen.

0:16.3

You're listening to Shortwave from NPR.

0:21.5

Hey, Shortwaver's Emily Kwong here.

0:24.1

And today, we're going to meet Dylan Pruitt, a genetics researcher at Florida State University

0:29.0

in the School of Communication Sciences and Disorders.

0:31.3

And the particular condition Dylan studies, it's been with him most of his life.

0:36.4

I started stuttering around age three throughout elementary school, was in speech therapy.

0:44.0

An estimated one in 100 people have a stutter, according to the National Institute of Health.

0:48.9

That's three million Americans, but it is still an understudied condition.

0:54.1

Dylan told us that even in college,

0:56.8

there wasn't a lot of robust scientific knowledge about stuttering,

1:00.0

what causes it,

1:00.9

and why some people who start stuttering in childhood eventually stop,

1:05.0

while others do not.

1:06.6

I had kind of heard like,

1:07.8

oh, there was some new studies that were looking at genetics of stuttering

1:13.7

and reached out to a professor and asked some questions.

1:18.3

And he was like, you know, honestly, this is a very new area.

1:21.4

I don't know a lot about it, but it's an area that needs a lot more research.

...

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