Hello and welcome to the Zero to Finals podcast.

My name is Tom and in this episode I'm going to be talking to you about

Stevens Johnson Syndrome and toxic epidermal necrolysis.

And you can find written notes on this topic at zero definals.com slash SJS

or in the dermatology section of the zero definals pediatrics book.

So let's get straight into it.

Stevens-Johnson syndrome, or S-J-S, and toxic epidermal necrolysis or T-E-N,

are a spectrum of the same pathology, where a disproportionate immune response causes

epidermal necrolysis, resulting in blistering and shedding of the top layer of the skin. Generally,

Stephen Johnson syndrome affects less than 10% of the body surface area, whereas toxic epidermal

necrolysis affects more than 10% of the body surface area, whereas toxic epidermal necrolysis affects more than 10% of the body area.

Certain HLA genetic types are associated with a higher risk of Stevens-Johnson syndrome and

toxic epidermal necrolysis. Let's talk about the causes. Firstly, medications such as anti-epileptics, antibiotics, allopurinol, and non-steroidal anti-inflammatory

drugs can be associated with the condition, and also infections such as herpesymplex,

mycoplasma pneumonia, cytomagolirus and HIV.

Let's talk about the presentation. The condition has a spectrum of severity. Some cases are mild,

whilst others are very severe and potentially life-threatening.

Patients usually start with non-cific symptoms of fever, cough,

sore throat, sore mouth, sore eyes and itchy skin.

They then develop a purple or red rash that spreads across the skin and starts to blister.

A few days after the blistering starts, the skin starts

to break down and shed, leaving the raw tissue underneath. Pain, erythema, blistering and shedding

...