SNR #123: Donald Layman, PhD - Leucine Kinetics, mTOR Activation & the Anabolic Response to Protein

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 31 May 2016

⏱️ 45 minutes

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Summary

Episode 123: Donald Layman PhD, professor emeritus at the University of Illinois, discusses the "leucine threshold" and activation of the mTOR pathway, amino acid oxidation and why MPS drops 2-3 hours after that peaking even when protein remains being fed.

Dr. Layman is professor emeritus at the University of Illinois.

Dr. Layman's laboratory is working to define protein and amino acid requirements and the interrelationship between dietary protein and carbohydrates in adult health. His research is focused on the impact of diet and exercise on adult health problems of obesity, type 2 diabetes and the Metabolic Syndrome.

We discuss:
What should we define as a "high-protein" diet?
Making protein recommendations on a per meal basis
The "leucine threshold" and activation of the mTOR pathway
Other metabolic signals triggered off by amino acids that play a role in health
The roles of insulin and leucine in mTOR activation - shifts in their contribution over time
Why oxidation of amino acids does not mean they are "wasted"
Why MPS drops 2-3 hours after that peaking even when protein remains being fed
Protein synthesis as an energy expensive process
Leucine kinetics
Protein leverage hypothesis

Transcript

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0:00.0	What we need to then think about is protein synthesis has two major stages.
0:13.0	One is the initiation stage, which leucine helps trigger these proteins that are called initiation factors.
0:20.0	And that's kind of like an
0:21.0	odd-off switch once we get it started then we have the very expensive elongation
0:26.5	phase and that phase seems to benefit from some additional protein and
0:31.3	certainly additional energy so most of us I think working in the field now
0:36.5	think that it's absolutely important that
0:38.9	you get to that 30 gram threshold to get things started.
0:42.5	And there's probably benefit up to maybe as much as 50 grams of protein out of meal. Hello and welcome to Sigma Nutrition Radio, the podcast that brings you evidence-based
1:10.3	discussions with the world's
1:11.8	leading researchers in fields related to nutrition and health. I am your host, Danny Lennon,
1:17.8	and you are listening to Episode 123. And today we are going to be joined by Dr. Donald Lehman,
1:25.8	who is a professor at the University of Illinois.
1:29.8	And Dr. Lehman's laboratory is working to define protein and amino acid requirements, and then
1:35.9	the interrelationship between dietary protein and carbohydrates in adult health.
1:40.9	And a lot of his research is focused on the impact of diet and exercise
1:45.0	on health problems of obesity, type 2 diabetes and metabolic syndrome, and all the interrelated
1:52.9	issues that crop up with those. Today we're going to discuss all sorts of topics related to
1:58.6	protein intakes and their effects, including issues like
2:02.3	the Lucene Threshold and the activation of the MTOR pathway, amino acid oxidation, and things
2:08.6	like why muscle protein synthesis drops two to three hours after peaking, even when protein
2:14.9	remains being fed.
	...

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