Hey guys how's it going? Today's topic is going to be about sepsis.

We're going to talk about the new definitions of sepsis, how these patients will present,

we're going to go over what to look for on physical exam, what labs to order, what tests to order, and finally, how do we treat these patients?

So let's jump right in in today's topic and talk about sepsis.

To understand sepsis, you must first understand that sepsis exists on a continuum of severity.

It starts with bactoremia and infection and progresses to sepsis and septic shock.

From there it can lead into multiple organ dysfunction

syndrome also known as mods and even death. Now let's break down the spectrum

of severity even further starting with infection and bacteria.

Infection can be defined when tissue that is normally sterile gets invaded by

organisms resulting in infectious pathology. For example, when the normal sterile tissue of the bladder gets

invaded by the enteric pathogenic E. coli, an infection is born in the name of

acute cystitis. Whereas bacteremia is simply defined as the presence of bacteria in the blood.

So why is this important? Because all patients with an infection or Bacteremia

technically have the potential to progress towards sepsis.

But will every acute stestitis, segolitis, pneumonia, advance to sepsis? Of course not.

And that's not what I'm trying to say. This is just a logical way to explain

the progression towards sepsis in a stepwise fashion that is easy to learn and understand.

Now in the past, the SERS criteria was used to help define sepsis,

but that has fallen out of favor for many reasons which we will not get into today.

Today we are going to be talking about the new criteria for defining

sepsis. The new criteria for sepsis was published in 2016 by the Society of

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