Behind the knife, the Surgery Podcast, where we take a behind the scenes intimate look at surgery

from leaders in the Knife Medical Student and Intern Survival Guide.

The Behind the Knife Medical Student and Intern Survival Guide is a surgical education podcast series that focuses on high-yield topics relevant to both

medical students and surgical interns. My name is Patrick Georgeoff and I'm

Vahag Nikolian and we are your hosts. We hope you're enjoying the

podcast. If you have any suggestions or requests, please shoot

us an email. Our addresses can be found in the show note.

All right, we've got a good one for you today. Septic Shock. This topic can be quite a bit more challenging than some of the others because it covers so much ground.

Yeah, it really doesn't fit into an algorithm or a chapter.

So that's why we're going to break it down for you in a clear concise and clinically relevant way.

First, we're going to cover the basic physiology of septic shock.

Then we'll talk about some of the controversy related to the new definitions of sepsis and finally we'll put it all together with a case scenario.

Yeah I don't think we can oversell this one vahawk. It is so critically important to recognize septic shock and to know how to treat it.

And while the overall mortality of septic shock has gone down in recent years, it's still

in the 20 to 30 percent range and that's even at the best centers around the world. And every hour you delay

the administration of antibiotics in a septic patient, mortality increases by 4%. 4%.

And this is really, it's the real deal.

It's something you should feel comfortable with before you start intern year.

Because this is one of those things where you could actually save someone's life.

I agree. So to get

things started let's take a step back and define shock. Shock is reduced organ

perfusion that results in cellular dysfunction. Now it's probably

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