Semaglutide: The Truth About the Magic Weight Loss Drug Hollywood Celebs Are Injecting
High Intensity Health with Mike Mutzel, MS
Mike Mutzel
4.8 • 1.2K Ratings
🗓️ 24 January 2023
⏱️ 13 minutes
🧾️ Download transcript
Summary
Semaglutide aka Ozempic is a GLP-1 agonist that's been around for a long time, suddenly Hollywood elites are now promoting it for fat loss. Here's the science you need to know.
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Research Mentioned:
Wilding, J. P. H. et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. New Engl J Med 384, 989–1002 (2021).
Sharma, D., Verma, S., Vaidya, S., Kalia, K. & Tiwari, V. Recent updates on GLP-1 agonists: Current advancements & challenges. Biomed Pharmacother 108, 952–962 (2018).
Show Notes:
0:20 Semiglutide is a GLP-1 agonist.
00:30 GLP-1, glucagon like peptide 1, functions under the category of gastrointestinal incretin hormones that helps you process the foods you eat. It improves insulin sensitivity. Decreases glucagon.
01:30 About 80% of the mechanisms of bariatric surgery is by amplifying the release of incretin hormones.
02:00 There was a 14% loss of body weight in study participants.
02:50 Semiglutide exerts stress on pancreatic beta cells, with an increased prevalence of pancreatitis and potentially pancreatic cancer.
04:40 GIP and GLP-1 are released after eating to increase insulin secretion from beta cells and prevent post-meal glucose excursions.
05:50 The diminished activity of GIP and GLP-1 is a feature of type-2 diabetes, beta cell insulin resistance, an obesity.
07:10 Exercise increases the release of gastrointestinal incretin hormones.
07:25 Berberine increases gut hormones and changes your microbiome.
07:40 These incretin hormones control the ecosystem of your gut microbiome and can improve function of immune cells around your gut.
08:10 Bifidobacterium can lead to a healthier GI incretin response.
09:00 GABA and L-glycine.
09:45 Protein and fat.
10:30 Polyphenols
Transcript
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| 0:00.0 | There's a lot of buzz lately about a diabetic drug called semi-glutide, and a lot of people |
| 0:03.4 | are trying to use this as an attempt to lose body fat. |
| 0:06.3 | In today's show, we're going to talk more about what semi-glutide is, how it works, and |
| 0:10.3 | whether or not you should consider semi-glutide if you're trying to lose weight. |
| 0:13.4 | And most importantly, are there other natural ways to mimic what semi-glutide does without |
| 0:18.5 | the potential downside? |
| 0:19.8 | So let's dive into what is semi-glutide. |
| 0:22.7 | It's a GLP1 agonist, essentially what that means is it's a synthetic way to agonize |
| 0:28.8 | the GLP1 receptor. |
| 0:30.6 | You're saying, okay, well, what is GLP1? |
| 0:33.1 | Glucogon-like peptide one. |
| 0:34.4 | There's two forms of this GLP1 and GLP2. |
| 0:37.6 | There's also a related hormone called GIP, GIP1, or GIP. |
| 0:41.9 | And these hormones are all function under the category of gastrointestinal increase in hormones. |
| 0:47.5 | This is a category of hormones that helps you in the post-male window process the foods |
| 0:52.9 | that you eat in the post-male window. |
| 0:54.8 | And that includes, but it is not limited to improving insulin sensitivity, decreasing |
| 1:00.1 | glucose. |
| 1:01.1 | All of the different post-male processing that occurs after you eat to maintain homeostasis |
| 1:05.8 | in the body. |
| 1:06.8 | And it turns out, an early phenotypic future of insulin resistance is a loss in the function |
| 1:12.6 | of these gastrointestinal increase in hormones. |
... |
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