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Police Off The Cuff/Real Crime Stories

Science doesn't lie the nancy Guthrie case breakdown.

Police Off The Cuff/Real Crime Stories

Bill Cannon Police off the Cuff/Real Crime Stories

Law Enforcement, Crime, True Crime, Military

4.4870 Ratings

🗓️ 17 April 2026

⏱️ 12 minutes

🧾️ Download transcript

Summary

The Nancy Guthrie case may have just reached a turning point. The FBI is now reportedly using advanced SNP DNA analysis on evidence taken from Nancy’s home, a powerful forensic method that could identify an unknown suspect and breathe new life into this haunting cold case. Retired NYPD Sgt. Bill Cannon breaks down how SNP DNA works, why investigators use it, and why this latest move could be the key to finally unlocking the truth. If this testing produces the results investigators hope for, it could mark the most important breakthrough in the Nancy Guthrie investigation in years.

Transcript

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0:00.0

Yeah, you know, Mike, just I don't want to hop on this, but there's also a chain of custody issue when you play games like this, right?

0:07.5

Chain of custody is you want the least amount of people touching evidence as possible because defense attorneys make their living off of that, make their living off of trying to disqualify evidence because too many people touched it.

0:21.6

And that's what, in the simplest way. That's what chain of custody is. Back to Brian Anton. Why would they need

0:28.5

to go to the FBI lab if they've already been sent to the Florida lab? I'm going to have

0:33.8

CC Moran in a second here. Genealogist and FBI and DNA expert to explain that.

0:40.2

And the answer is actually very interesting.

0:42.4

And I'm going to let her explain it because she can explain it much better than I am, can because she's the expert.

0:48.6

Also, Pima County Sheriff put out a statement regarding this new reporting.

0:51.9

They say Pima County Sheriff's Department

0:54.5

has worked with the FBI since the beginning

0:56.3

of the Guthrie investigation.

0:57.9

This is not new information.

0:59.8

The private lab we utilize in Florida

1:01.4

continues to share information with the FBI lab

1:04.0

and other partner labs across the country.

1:06.5

DNA analysis remains ongoing.

1:09.2

And when they say other partner labs across the country,

1:12.7

this is because, remember, they've been having issues with some of the DNA that is mixed.

1:17.9

And to separate it out can be a complicated process. So other labs may have different technology.

1:25.9

The FBI may have different technology, which is why this evidence is now being sent out to the FBI to test.

1:31.3

But again, the hairs in particular are interesting,

1:35.3

and that's what I want to talk to C.C. more about and find out, you know, is this progress?

...

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