S1E23 / Our Immune System versus the Virus / Stanley Perlman & Jon Yewdell

EPIDEMIC with Dr. Celine Gounder

KFF Health News and Just Human Productions

Science, #Coronavirus, Health & Fitness, #Smallpox, Documentary, #Covid19, #Sarscov2, #Eradication, Life Sciences, Society & Culture, #Covid, Medicine

4.6 • 1K Ratings

🗓️ 26 May 2020

⏱️ 21 minutes

🔗️ Recording | iTunes | RSS

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Summary

“Antibodies are the easiest part of the immune system to measure. It's not the only part that's required for protection against this virus.” - Stanley Perlman In today’s episode, co-hosts Dr. Celine Gounder and Ron Klain continue their discussion of the immune system. They speak with Stanley Perlman and Dr. Jon Yewdell about what happens when a virus enters the body and the different types of cells involved in each stage of the immune response against the virus. They talk about what is known so far about how the immune system reacts to a COVID infection and the degree of immunity that results post-infection. They also discuss how understanding the immune response is an important factor in developing an effective vaccine for COVID and putting an end to the current pandemic. Stanley Perlman is a professor of microbiology, immunology and pediatric infectious diseases at the University of Iowa. Dr. Jon Yewdell is a researcher at the National Institutes of Allergy and Infectious Diseases, where he studies viruses, immunity to viruses, and the cell biology of viral infections. This podcast was created by Just Human Productions. We're powered and distributed by Simplecast. We're supported, in part, by listeners like you. #SARSCoV2 #COVID19 #COVID #coronavirus

Transcript

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0:00.0	I'm Dr. Saline Gounder and I'm Ron Klein. And I'm Ron Klain. And this is epidemic.
0:16.0	Today is Tuesday, May 26th.
0:21.3	Saline, we saw recently as states began to reopen.
0:24.8	A lot of people cavalier about getting together in large groups, including a massive pool
0:30.4	party at the Lake of the Ozarks that was all over social media last weekend.
0:37.2	That one and others were not small get-togethers.
0:42.2	People may believe that even if they get COVID at one of these
0:45.1	gatherings they'll get sick get over it and then be immune but it may not work out
0:50.3	that way. Here's Stanley Perlman, a professor of microbiology,
0:54.7	immunology, and pediatric infectious diseases at the University of Iowa.
0:58.8	If the system is working well, what we know is that people will develop an antibody response. And the
1:07.0	antibody response will, we hope be protective and most of the time it is but sometimes it's not and that's what we need
1:16.5	to investigate with this infection if you get an antibody response is it really protective
1:21.9	and even if an antibody response is protected is a part of the immune system to measure. But it's not the only part that's required
1:34.5	for protection against this virus. So what else is required? That's what
1:40.2	researchers are racing to find out.
1:42.6	And today, two veteran scientists
1:45.1	join us to explain what they're seeing
1:47.0	in their initial investigations of SARS COV2.
1:51.0	We'll explore what happens when a virus enters the body, how the immune system reacts,
1:56.0	and how a deeper understanding of this response is the first step towards developing a vaccine.
2:02.1	And what everyone's dreaming about, an end to this pandemic.
	...

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