Hey, friends. Welcome back. So in today's session, we're going to examine if there's any connection between consuming red meat and also protein and its correlations or links with cancer and focus on a specific molecular target that many people like to talk about when they make associations mechanistically with consuming red meat and protein and its links with cancer and that is IGF one insulin like growth factor one.

There was a paper that I was made aware of by Dr. Gabrioline and Stu Phillips on a recent podcast and I want to play that clip shortly but first talk to you about this paper and some problems associated with this paper as it pertains to the links between protein consumption and IGF one increases and that mechanistically causing neoplastic formation or formation of cancerous cells.

The title of the paper here is low protein intake is associated with a major reduction in IGF one cancer and overall mortality in the 65 and younger but not older population.

So I think this is an important paper to talk about because it was published in some metabolism in 2014. It has since been cited over a thousand times, meaning it's in a high impact journal and is considered a high impact paper because many other people and authors and investigators are referencing this on an IGF one.

You know as part of their work and the problem here in as do Phillips will explain very shortly as he was interviewed by Dr. Gabrioline who we've had on our podcast several times they examine the nutritional epidemiological data that was analyzed as part of this paper that used a cellular model a mechanistic model combined with the epidemiological data in humans now the problem here in as do will explain is the data set is quite small.

Making the associations with increased consumption of cancer making that relative risk appear to be worse than it really is with regards to protein consumption and it's links with cancer okay so after the clip we're going to talk more about IGF one because this has been really oversimplified by many people who are activists and and proponents of going on a vegetarian or a vegan diet for fear that if you consume protein what that is going to do in your body is not going to be good.

Is go out and cause cancer because it increases IGF one because this paper said so now the problem is it's not that simple as you will soon learn insulin like growth factor one adheres to a you shaped relationship and you shape curve with overall disease causation and mortality low levels of IGF one is actually as bad as having chronically elevated levels of IGF one it's like many things in life there's a balance here so I want to continue to dive into.

The mechanisms about what IGF one does how what causes it to increase your decrease and what are the favorable effects of IGF one because guess what you hear about IGF one and it's links with causing cancer and

disease but there's also favorable things that actually increase IGF one like exercise IGF one has been shown to increase during exercise up to 20 fold so on the one hand you have activists saying if you eat red meat it will cause cancer by way of increasing IGF one

now you say well okay if that was true then wouldn't exercise also cause cancer because exercise acutely increases IGF one like everything there's nuance and there's context that we need to understand and differentiate and tease out so that's where we're going today but first let's listen to this clip and there's interview as part of doctor Gabriel lines podcast and here is two Phillips and I think you'll enjoy this little segment and then we'll unpack it and further get into the details of IGF one

but when you say cancer risk is four times greater in one group versus another you know it's it's it's more than half the effect of smoking that is a that is a huge effect and so really the effect in that paper is an artifact of the very small numbers of people they had that actually had cancer and died from cancer and so you know once you get down to small numbers like a few sort of blips here and there make big differences and so

relative risks in that sense are huge if you took those data out of that paper and submitted them to any decent nutrition journal worth its salt it wouldn't have been published so I just think that the people at cell metabolism who got their hands on that paper looked a little exclusively or almost exclusively at the molecular data and and it's it's astonishing it's very very good and you know vaulted long ago it tells a great story about

a particular type of individuals who have a form of dwarfism who lack a growth hormone receptor who have no cancer and I mean that's an astonishing finding and it's a genetic obviously mutation that results in people who are short in stature but it certainly indicates that these growth factors do play a role in the development of cancer the endhane's data that accompanied that analysis it was in my opinion very poorly done so his

group is going to go on and use a much broader analysis of the endhane's data set to actually make the relative risk not not not manipulate the data in a way but to give it a more accurate representation of the and to investigate if there is any connection between protein intake

and its association with cancer again because the data set that was used as he just articulated in the cell metabolism paper was so small and so what that that created

that over exaggerated the effect size that protein consumption would have on cancer because as he went on to say and I sort of chopped up the clip a little bit

that what this paper insinuated is the effect size of protein and it's increasing protein consumption had the effect size almost on par with smoking which we all know that that is probably over

exaggerated and so again his group within the year of 2022 is going to use a broader data set including more people that have actually died of cancer and looking at the associations if there is any so

I think that's important and I do want to thank every online for putting out great content but we're going to continue on and talk more about IGF1 because again this has been proposed to be the molecular connection between sort of bridging the physiology mechanistically with eating red meat and

protein and causing the formation of cancer is because the theory goes the thinking goes that because protein is associated with increasing insulin like row factor one and therefore driving the cellular processes that are linked with cancer that is why that individuals propose that we no longer consume red meat weed bugs or legal and Keen Mar or soy or some such things well let's look at the connections here if there is any with IGF1 elevation

in its formation with cancer and dive into that but first I mentioned exercise friends exercise is very protective it's neuroprotective cardiovascular

protective and so we're always looking for solutions for high intensity health and my own science to support your exercise sessions so the electrolyte sticks are

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