Rams' offense dominates depleted 49ers in NFC West showdown

49ers Talk: A San Francisco 49ers Podcast

NBC Sports Bay Area

Nfl, Football, Matt Maiocco, San Francisco 49ers, Sports

4.6 • 988 Ratings

🗓️ 10 November 2025

⏱️ 45 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Matthew Stafford and the Rams' high-powered offense overpowered a 49ers defense reeling from injuries on Sunday, handing San Francisco its first divisional loss with a 42-26 defeat. The 49ers remain locked in the NFC West's third-place spot, fighting for health and positioning as the playoff picture starts to crystallize in the season's second half. On this episode of "49ers Talk," co-hosts Matt Maiocco and Jennifer Lee Chan break down San Francisco's performance against the Rams in Week 10, from an inexperienced defense decimated by injuries to an offense expected to protect such deficiencies despite its own missing pieces. Matt and Jennifer help make sense of how San Francisco can contend moving forward in a highly competitive divisional and conference environment.

Transcript

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0:19.0	The 49ers one week up, one week down stretch of games continued on Sunday at Levi Stadium.
0:26.6	Against their division rivals, the LA Rams, it was a downturn for the 49ers.
0:31.6	The 49ers defense simply could not keep up with Matthew Stafford and the Rams on this day, and the 49ers fall
0:38.8	up pegged down in the division, as well as in the race to be one of the top seven teams in the
0:43.5	NFC. Mac Jones and George Kittle had a good day, but the team as a whole made too many mistakes
0:49.7	to keep up with the Rams on this day. Jennifer Lee Chan was there and we'll talk about where things
0:55.2	went wrong in their 42 to 26 loss to the Rams in week 10 of the NFL season. We'll have all
1:01.0	that and much more on this episode of 49ers talk coming at you right now. Welcome to another episode of
1:07.4	49ers talk on NBC Sports Bay Area.com. Introducing your hosts, Matt Mayoko and Jennifer
1:15.0	Lee Chan. All right, this is 49ers talk brought to you by Big O tires. Shop top brand tires with the
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1:28.2	oh the team you trust well the 49ers had an opportunity to really take the NFC west
1:37.1	maybe not control of it because Seattle's winning up there so they're they're staying right there with a seven and two record.
1:47.0	But to be able to start off with three wins in the division,
1:51.0	four years are really in good shape.
1:54.0	But then the Rams came to town and it was a different ballgame, wasn't it?
1:58.0	It was. I talked to Tadem Bethune, and he kind of said it the best.
2:03.2	There just was not execution on the defense, and basically Matthew Stafford manhandled the
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