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The Dr. Hyman Show

Psychedelics, Depression, and the Brain: A Breakthrough Framework for Mental Health

The Dr. Hyman Show

Dr. Mark Hyman

Health & Fitness, Nutrition, Medicine

4.6 • 8.7K Ratings

🗓️ 16 July 2025

⏱️ 95 minutes

🧾️ Download transcript

Summary

What if the key to healing depression isn’t another pill but a profound shift in consciousness? On this episode of The Dr. Hyman Show, I talk with Dr. Robin Carhart-Harris, one of the world’s leading psychedelic researchers, about how these compounds unlock plasticity in the brain and offer new hope for people with treatment-resistant mental health challenges. From trauma recovery to the entropic brain principle, this is a conversation that challenges everything we think we know about the mind. You can watch the full episode on YouTube - https://youtu.be/P0EDsfPwbUQ In this episode, you’ll learn: • What happens in the brain during a psychedelic experience and why it matters • How the right set, setting, and support can shape the outcome of your healing journey • Why some people improve after one session, while others need a longer path • The risks of self-medicating and how to explore psychedelics safely • How emerging tools, including AI, could help personalize treatment and improve recovery If you’re curious about the healing potential of psychedelics, this is an honest, research-backed conversation worth tuning into. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detoxJoin the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by BON CHARGE, PerfectAmino, Timeline and Big Bold Health. Head to boncharge.com and use code DRMARK for 15% off your order. Go to bodyhealth.com and use code HYMAN20 for 20% off your first order. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today. Get 30% off HTB Immune Energy Chews at bigboldhealth.com and use code DRMARK30.

Transcript

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0:00.0

Coming up on this episode of the Dr. Hyman Show, it seems like a quantum jump, both the metabolic

0:04.9

psychiatry and psychedelic psychiatry.

0:07.3

I do see it as like a system reset and then back to sort of default function.

0:12.2

The idea is that we've become injured by life, adversity, trauma, get reinforced in a particular

0:18.3

way, perhaps for defensive reasons.

0:20.5

But I think there's something to it. I don't think it's all defensive reasons, but I think there's something

0:21.5

to it. I don't think it's all of it, but I do think it's a shake-up, a recalibration of the

0:27.5

parameters, if you want.

0:29.0

Robin Carhart Harris is a neuroscientist and leading researcher in psychedelic therapy, known for

0:34.6

his groundbreaking studies on psilocybin and mental health. What we're finding with these compounds is one, two, three sessions seems to do the trick.

0:42.3

Our first patient had been on, I don't know how many antidepressants.

0:46.3

And this got it well and she's still well.

0:48.3

So it can turn things around.

0:50.3

It seemed like they're sort of cracking open on pathways for people to explore around

0:53.3

getting relief from really intractable problems that create so much human suffering.

1:02.6

After my recent back surgery, I was looking for ways to gently support my body's recovery.

1:07.1

And one of the most helpful tools I found is the infrared PEMF mat from bond charge. It uses

1:11.6

low-level infrared heat combined with pulsed electromagnetic fields to support circulation,

1:16.0

ease tension, and encourage the body's natural repair processes. I've incorporated it into my

1:20.0

routine after physical therapy and long days on my feet, and I found it to be a helpful part

1:24.1

of managing post-surgical discomfort and promoting relaxation. It's simple to use, just lie down, breathe, and let the warmth and pulses do their work. I've noticed it helps me wind down and feel more at ease, especially in my lower back. If you're navigating pain, stiffness, or just want to support your recovery at home, it's a thoughtful tool to explore. Head to bondcharge.com and use code DR mark for 15% off your order. That's B-O-N-C-H-A-R-G-E.com, code DR-Mark. There's a big misconception about protein, and it's one that can hold you back from real results. You see, our bodies don't use whole protein directly. Instead, they break it down into amino acids. The true building blocks your body uses to create muscle, skin, bone, and more. But not all amino acids are used equally. Some go toward

2:05.6

rebuilding tissue, while others, especially if they're in excess, may be converted into energy

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